Baseline Angina in Patients with Severe Aortic Stenosis and Coronary Artery Disease: A Secondary Analysis of the NOTION-3 Randomized Controlled Trial

Abstract Background Angina is common in patients with coronary artery disease and severe aortic stenosis. Whether angina should guide coronary revascularization in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI) remains uncertain. Aims To assess whether angina modifies the effect of percutaneous coronary intervention (PCI) on clinical outcomes and whether percutaneous coronary intervention influences angina burden after TAVI. Methods and results This prespecified secondary analysis of the NOTION-3 trial included patients with severe aortic stenosis and significant coronary artery disease randomized to TAVI with percutaneous coronary intervention or optimal medical therapy (OMT). Baseline angina was assessed by Seattle Angina Questionnaire-7 Angina Frequency score, supplemented by Canadian Cardiovascular Society class when questionnaire data were missing. Of 454 patients, 229 (50%) had angina and 225 (50%) had no angina. In the baseline angina subgroup, the primary outcome MACE, a composite of death from any cause, myocardial infarction, or urgent revascularization, occurred in 27% randomized to PCI versus 37% randomized to OMT. Without angina, rates were 26% versus 35%. Hazard ratios for PCI versus OMT were 0.71 (95%-CI 0.45–1.13) in patients with angina and 0.69 (95%-CI 0.43–1.12) in those without, with no interaction by baseline angina (P=0.97). SAQ-7 summary scores improved at 1 year in angina groups, with no between-group difference in change (16 vs. 17; P=0.78). Conclusion We found no evidence that baseline angina modified the relative effect of PCI on clinical outcomes, although the study was not powered to exclude clinically meaningful heterogeneity.

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Journal
European Heart Journal - Valvular and Structural Heart Disease
Published
2026-06-16
DOI
https://doi.org/10.1093/ehjvshd/xwag047
Primary Topic
Cardiac Valve Diseases and Treatments
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article
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article

Baseline Angina in Patients with Severe Aortic Stenosis and Coronary Artery Disease: A Secondary Analysis of the NOTION-3 Randomized Controlled Trial

Troels Højsgaard Jørgensen, Lene Holmvang, Gintautas Bieliauskas, Mikko Savontaus et al.
European Heart Journal - Valvular and Structural Heart Disease
Cardiac Valve Diseases and Treatments
article

Baseline Angina in Patients with Severe Aortic Stenosis and Coronary Artery Disease: A Secondary Analysis of the NOTION-3 Randomized Controlled Trial

Troels Højsgaard Jørgensen, Lene Holmvang, Gintautas Bieliauskas, Mikko Savontaus, Dan Ioanes, Jarkko Piuhola, Muhammad Sabbah, Thomas Engstrøm, Phillip Freeman, Rikke Sørensen, Oskar Angerås, Charlotte Glinge, Jacob Thomsen Lønborg, Rickard Linder, Ashkan Eftekhari, Jasmine Melissa Marquard, M Niemela, Pasi Karjalainen, Evald Christiansen, Christian Juhl Terkelsen, Casper Ferreira Zimmer, Olli Kajander, Reza Jabbari, Andreas Rück, Ole De Backer, Lars Søndergaard, Karsten Tange Veien, Sasha Koul
article en

Abstract

Abstract Background Angina is common in patients with coronary artery disease and severe aortic stenosis. Whether angina should guide coronary revascularization in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI) remains uncertain. Aims To assess whether angina modifies the effect of percutaneous coronary intervention (PCI) on clinical outcomes and whether percutaneous coronary intervention influences angina burden after TAVI. Methods and results This prespecified secondary analysis of the NOTION-3 trial included patients with severe aortic stenosis and significant coronary artery disease randomized to TAVI with percutaneous coronary intervention or optimal medical therapy (OMT). Baseline angina was assessed by Seattle Angina Questionnaire-7 Angina Frequency score, supplemented by Canadian Cardiovascular Society class when questionnaire data were missing. Of 454 patients, 229 (50%) had angina and 225 (50%) had no angina. In the baseline angina subgroup, the primary outcome MACE, a composite of death from any cause, myocardial infarction, or urgent revascularization, occurred in 27% randomized to PCI versus 37% randomized to OMT. Without angina, rates were 26% versus 35%. Hazard ratios for PCI versus OMT were 0.71 (95%-CI 0.45–1.13) in patients with angina and 0.69 (95%-CI 0.43–1.12) in those without, with no interaction by baseline angina (P=0.97). SAQ-7 summary scores improved at 1 year in angina groups, with no between-group difference in change (16 vs. 17; P=0.78). Conclusion We found no evidence that baseline angina modified the relative effect of PCI on clinical outcomes, although the study was not powered to exclude clinically meaningful heterogeneity.

European Heart Journal - Valvular and Structural Heart Disease
University of Copenhagen (DK), Karolinska University Hospital (SE), University of Helsinki (FI), Tampere University of Applied Sciences (FI), Oulu University Hospital (FI), Aalborg University Hospital (DK), Helsinki University Hospital (FI), Sahlgrenska University Hospital (SE), Odense University Hospital (DK), Turku University Hospital (FI), Aarhus University Hospital (DK), Copenhagen University Hospital (DK), Rigshospitalet (DK), Karolinska Institutet (SE), Abbott (United Kingdom) (GB), Glanrhyd Hospital (GB), Pirkanmaa Hospital District (FI), Tampere University (FI), Skåne University Hospital (SE)
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Cardiac Valve Diseases and Treatments
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