Self-lubricating anticoagulant surface (SLACS) mimicking heart valve tissue for improving biocompatibility of artificial blood pumps
Extracellcular membrane oxygenation (ECMO) is the most advanced form of extracorporeal life support. Its centrifugal pump head, a key component in contact with blood, requires excellent blood compatibility for optimal performance. To address this need, a self-lubricating anticoagulant surface (SLACS) was fabricated on a roughened stainless steel substrate via physical adhesion and chemical bonding using a dimethylsiloxane gel (S-PDMS). SLACS demonstrates exceptional resistance to blood adhesion, leading to superior blood compatibility. Coating the ECMO centrifugal pump head with SLACS significantly enhanced its performance. The feasibility of SLACS as a novel coating was confirmed through static tests, computational simulations, and dynamic experiments, offering a promising solution to improve the safety of ECMO therapy.
Authors
- Yaoyao Chen (ORCID: https://orcid.org/0009-0006-5908-7958)
- Xiaodan Gou
- Lihong Fan (ORCID: https://orcid.org/0000-0001-8277-4007)
- Ying He (ORCID: https://orcid.org/0000-0003-0110-8497)
- Shiyu Cui (ORCID: https://orcid.org/0000-0003-1305-2259)
- Xi Zhang (ORCID: https://orcid.org/0000-0002-4638-3997)
- Feng Chen (ORCID: https://orcid.org/0000-0002-7031-7404)
- Yuhua Ren
- Jun Zhong (ORCID: https://orcid.org/0000-0002-9376-4784)
- Cheng Yang (ORCID: https://orcid.org/0000-0002-0071-2273)
- Qing Yang
- Wei Wang
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- First Hospital of Xi'an (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Biomedical Materials
- Published
- 2026-06-16
- DOI
- https://doi.org/10.1088/1748-605x/ae7e2f
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China