Aging, Genetic Susceptibility and Risk of Chronic Inflammatory Upper Airway Diseases: Finding From A Prospective Cohort Study
Summary PhenoAge acceleration consistently associates with incident CRSwNP and CRSsNP, but not AR. Accelerated biological aging mediates 19.5% and 26.4% of smoking's pathogenic effects on CRSsNP and CRSwNP, respectively.
Authors
- Yi‐Ke Deng
- J X
- Ziwei Zhu (ORCID: https://orcid.org/0000-0002-3990-4774)
- Chaolong Wang (ORCID: https://orcid.org/0000-0003-3945-1012)
- Yin Yao (ORCID: https://orcid.org/0000-0002-5833-5263)
- Yan Nie (ORCID: https://orcid.org/0000-0002-8111-6050)
- Zheng Liu (ORCID: https://orcid.org/0000-0002-4168-6702)
- Zhuo Xu (ORCID: https://orcid.org/0000-0001-5420-5966)
- Wen‐Xuan Xiang
- Ao Huang
- Jia Song
- Heng Wang
Institutions
- Wuhan University (CN)
- Wuhan Prevention and Treatment Center for Occupational Diseases (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Tongji Hospital (CN)
- Wuhan University of Science and Technology (CN)
- Huazhong University of Science and Technology (CN)
- Hubei University (CN)
- Wuhan Sports University (CN)
- Wuhan Institute of Technology (CN)
Publication Details
- Journal
- Clinical & Experimental Allergy
- Published
- 2026-06-16
- DOI
- https://doi.org/10.1111/cea.70371
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China