Seven security challenges in cross-domain multi-agent LLM systems

Large language models are evolving into autonomous agents that collaborate across organizations for tasks like disaster response and supply-chain optimization. However, such cooperation breaks unified trust assumptions: a benign agent may leak secrets or violate policy when interacting with untrusted peers. This paper maps the security agenda for cross-domain multi-agent LLM systems, introducing seven categories of novel challenges alongside plausible attacks, evaluation metrics, and research directions.

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Publication Details

Journal
npj Artificial Intelligence
Published
2026-06-13
DOI
https://doi.org/10.1038/s44387-026-00128-9
Primary Topic
Adversarial Robustness in Machine Learning
Type
article
Field-Weighted Citation Impact
0.00
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article

Seven security challenges in cross-domain multi-agent LLM systems

Ronny Ko, Makoto Onizuka, Shuyuan Zheng, Chuan Xiao et al.
npj Artificial Intelligence
Adversarial Robustness in Machine Learning
article

Seven security challenges in cross-domain multi-agent LLM systems

Ronny Ko, Makoto Onizuka, Shuyuan Zheng, Chuan Xiao, J Chung, Won-Yong Shin, Tae-Wan Kim
article en

Abstract

Large language models are evolving into autonomous agents that collaborate across organizations for tasks like disaster response and supply-chain optimization. However, such cooperation breaks unified trust assumptions: a benign agent may leak secrets or violate policy when interacting with untrusted peers. This paper maps the security agenda for cross-domain multi-agent LLM systems, introducing seven categories of novel challenges alongside plausible attacks, evaluation metrics, and research directions.

npj Artificial Intelligence
Seoul National University (KR), Yonsei University (KR), Sensor Electronics (United States) (US), The University of Osaka (JP)
Climate action
Openalex Percentile: Top 3%
Adversarial Robustness in Machine Learning
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Seven security challenges in cross-domain multi-agent LLM systems — Ronny Ko, Makoto Onizuka, et al. · npj Artificial Intelligence (2026) | TGRS Research Map | TGRS