Ions as Stabilizers or Disruptors of Groove-Specific Hydration Architecture: A Geometric–Temporal Continuation

This publication develops a geometric–temporal framework in which ions are considered not only as electrostatic charges, but as ion-hydration regimes capable of stabilizing or disrupting groove-specific hydration architecture. The central thesis is that ions modify the local water architecture around DNA grooves, and through this modification affect hydration readability and the DNA–enzyme meeting window.