FORMULATION AND EVALUATION OF TOPICAL PATCHES OF MICONAZOLE NITRATE

Miconazole nitrate, an antifungal agent, is widely used for the treatment of various fungal infections. The development of topical patches as a delivery system for miconazole nitrate aims to enhance localized drug delivery, minimize systemic absorption, and improve patient compliance. This study focuses on the formulation and evaluation of miconazole nitrate topical patches using a solvent casting technique. Patches were prepared using biocompatible polymers such hydroxypropyl methylcellulose grades includes HPMC K100M, HPMC K4M, HPMC E50, along with plasticizers to optimize flexibility and adhesion. The patches were evaluated for physical properties, including thickness, tensile strength, and moisture content, In vitro drug release studies were conducted using diffusion cells, revealing a sustained released profile conducive to effective fungal treatment. Permeability studies demonstrated that the patches can achieve therapeutic concentrations in the skin layers. Overall, the developed miconazole nitrate topical patches show promising potential as an effective and patient-friendly alternative management of localized fungal infections.