Comment on ‘Context, not class, may be the key signal in systemic JAK inhibitor exposure in MF/SS’: reply from authors

The effects of systemic JAKis exposure in MF/SS appear context dependent and should not be interpreted as a homogeneous entity. Although disease worsening was observed in several patients initially diagnosed with presumed inflammatory dermatoses, causality cannot necessarily be inferred and may reflect, among other factors, underlying MF/SS biology, referral bias, or concurrent immunosuppressive influences. In post-transplant MF/SS patients receiving JAKis for graft-versus-host disease, MF/SS progression may reflect impaired immune surveillance or other disease-related factors rather than a direct effect of JAKis. These findings underscore the complexity of interpreting JAKi exposure in MF/SS and highlight the need for prospective studies to better define risks across clinical settings.

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Publication Details

Journal
British Journal of Dermatology
Published
2026-06-13
DOI
https://doi.org/10.1093/bjd/ljag240
Primary Topic
Inflammatory Myopathies and Dermatomyositis
Type
article
Field-Weighted Citation Impact
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article

Comment on ‘Context, not class, may be the key signal in systemic JAK inhibitor exposure in MF/SS’: reply from authors

Paula Enz, Emily Avitan‐Hersh, José Antônio Sanches, Keila Mitsunaga et al.
British Journal of Dermatology
Inflammatory Myopathies and Dermatomyositis
article

Comment on ‘Context, not class, may be the key signal in systemic JAK inhibitor exposure in MF/SS’: reply from authors

Paula Enz, Emily Avitan‐Hersh, José Antônio Sanches, Keila Mitsunaga, Stefanie Porkert, Emmilia Hodak, Yael A. Leshem, Erika Morsia, Iris Amitay‐Laish, Constanze Jonak, P Ortiz-Romero, A de Masson, Vasiliki Nikolaou
article en

Abstract

The effects of systemic JAKis exposure in MF/SS appear context dependent and should not be interpreted as a homogeneous entity. Although disease worsening was observed in several patients initially diagnosed with presumed inflammatory dermatoses, causality cannot necessarily be inferred and may reflect, among other factors, underlying MF/SS biology, referral bias, or concurrent immunosuppressive influences. In post-transplant MF/SS patients receiving JAKis for graft-versus-host disease, MF/SS progression may reflect impaired immune surveillance or other disease-related factors rather than a direct effect of JAKis. These findings underscore the complexity of interpreting JAKi exposure in MF/SS and highlight the need for prospective studies to better define risks across clinical settings.

British Journal of Dermatology
Marche Polytechnic University (IT), Université Paris Cité (FR), Rabin Medical Center (IL), Rambam Health Care Campus (IL), Saint Louis University Hospital (US), Hospital Italiano de Buenos Aires (AR), Research Institute Hospital 12 de Octubre (ES), Andreas Sygros Hospital (GR), Hôpital Saint-Louis (FR), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR), Medical University of Vienna (AT)
Good health and well-being
Openalex Percentile: Top 6%
Inflammatory Myopathies and Dermatomyositis
DOISourceOpenAlex
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