Human CD24+ dental papilla cells are competent seed cells for dentin-pulp regeneration via BMP2/SIRT1 axis
hDPCs represent a regeneration-competent subpopulation that integrates mitochondrial metabolism and signaling crosstalk to enable coordinated dentin-pulp regeneration, representing a translationally relevant cell source for dental tissue engineering.
Authors
- Qiuyu Chen (ORCID: https://orcid.org/0000-0003-0644-6356)
- Zhonghan Li (ORCID: https://orcid.org/0000-0001-5752-3417)
- Tiantian Hu (ORCID: https://orcid.org/0000-0002-2695-4262)
- Fei Bi (ORCID: https://orcid.org/0000-0003-4450-0114)
- Bohuai Zhou (ORCID: https://orcid.org/0009-0002-8206-6734)
- Wu Wx
- Tian Chen (ORCID: https://orcid.org/0000-0003-1296-7772)
- Gao Y (ORCID: https://orcid.org/0000-0003-2059-3168)
- Weidong Tian
- Cong Han
- Ding Bai
- Yiping Chen
- Jie Li
- Zhi Liu
- Chengcheng Liao
- Cheng Liang
- Jingyi Zhang
Institutions
- Tulane University (US)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Stomatology Hospital (CN)
- State Key Laboratory of Oral Diseases
Publication Details
- Journal
- Nature Communications
- Published
- 2026-06-12
- DOI
- https://doi.org/10.1038/s41467-026-74348-7
- Primary Topic
- Bone and Dental Protein Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China
- Department of Science and Technology of Sichuan Province