An Iron-Based MRI Probe with Tunable Spin State for Bioorthogonally Catalyzed Activation Imaging

species under photophysical conditions. This transition led to over a 100-fold enhancement in relaxivity with a high turnover number (>200), generating robust MRI contrast. The ruthenium complex was conjugated to bovine serum albumin and predelivered to the tumor site. In vivo bioorthogonal catalysis was subsequently demonstrated in a subcutaneous tumor model. At the tumor site, the catalyst specifically triggers a "turn-on" in relaxivity of the MRI probe, producing markedly enhanced MRI contrast via bioorthogonally catalyzed activation. By combining the specificity of bioorthogonal chemistry with the MRI probe with a tunable spin state, this work establishes the potential of the spin-modulated probe for targeted imaging with low background signals and high imaging contrast.

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Publication Details

Journal
Journal of the American Chemical Society
Published
2026-06-12
DOI
https://doi.org/10.1021/jacs.6c04653
Primary Topic
Lanthanide and Transition Metal Complexes
Type
article
Field-Weighted Citation Impact
0.00

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article

An Iron-Based MRI Probe with Tunable Spin State for Bioorthogonally Catalyzed Activation Imaging

Jun Shen, Yangjin Dong, Zulu Yang, Yingying Ning et al.
Journal of the American Chemical Society
Lanthanide and Transition Metal Complexes
article

An Iron-Based MRI Probe with Tunable Spin State for Bioorthogonally Catalyzed Activation Imaging

Jun Shen, Yangjin Dong, Zulu Yang, Yingying Ning, Song Wei Gao, Dongye Li, Yanhui Guo, Jiahao Chen
article en

Abstract

species under photophysical conditions. This transition led to over a 100-fold enhancement in relaxivity with a high turnover number (>200), generating robust MRI contrast. The ruthenium complex was conjugated to bovine serum albumin and predelivered to the tumor site. In vivo bioorthogonal catalysis was subsequently demonstrated in a subcutaneous tumor model. At the tumor site, the catalyst specifically triggers a "turn-on" in relaxivity of the MRI probe, producing markedly enhanced MRI contrast via bioorthogonally catalyzed activation. By combining the specificity of bioorthogonal chemistry with the MRI probe with a tunable spin state, this work establishes the potential of the spin-modulated probe for targeted imaging with low background signals and high imaging contrast.

Journal of the American Chemical Society
Ministry of Education of the People's Republic of China (CN), Sun Yat-sen University (CN), Sun Yat-sen Memorial Hospital (CN), National Engineering Research Center of Electromagnetic Radiation Control Materials (CN), South China University of Technology (CN)
National Natural Science Foundation of China, State Key Laboratory of Luminescent Materials and Devices, Young Scientists Fund, National Key Research and Development Program of China, Fundamental Research Funds for the Central Universities
Openalex Percentile: Top 13%
Lanthanide and Transition Metal Complexes
DOISourceOpenAlex
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An Iron-Based MRI Probe with Tunable Spin State for Bioorthogonally Catalyzed Activation Imaging — Jun Shen, Yangjin Dong, et al. · Journal of the American Chemical Society (2026) | TGRS Research Map | TGRS