The tissue-specific regulation of immunobiology by IL-17 signaling
IL-17 family cytokines are central regulators of tissue immunity. Here, we review recent advances in defining the cell- and tissue-specific activities of IL-17, emphasizing the signaling pathways engaged by IL-17 receptor (IL-17R) complexes and their associated downstream pathways. We highlight the intersecting transcriptional and posttranscriptional mechanisms that determine IL-17-driven responses and that underlie functional diversity across tissues. Last, we discuss emerging roles for IL-17 signaling in immunometabolism, neuroimmune interactions, cancer, and the latest approaches for targeted therapies.
Authors
- Shachi Vyas (ORCID: https://orcid.org/0000-0003-2034-783X)
- Rami Bechara (ORCID: https://orcid.org/0000-0002-1611-0242)
- Sarah L. Gaffen (ORCID: https://orcid.org/0000-0001-8511-2041)
- Peter Dráber (ORCID: https://orcid.org/0000-0001-8658-4614)
- Yang Li (ORCID: https://orcid.org/0000-0001-6743-4004)
Institutions
- Inserm (FR)
- University of Pittsburgh (US)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- CEA Paris-Saclay (FR)
- University of Lausanne (CH)
Publication Details
- Journal
- Science Immunology
- Published
- 2026-06-12
- DOI
- https://doi.org/10.1126/sciimmunol.adq6406
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Association Neurofibromatoses et Recklinghause
- National Institutes of Health
- Graduate School, Prince of Songkla University