Longitudinal prediction of biological aging: replication and extension of DunedinPACNI
Abstract DunedinPACNI is a new brain-based aging biomarker derived from cross-sectional MRI data. This study extended previous work by testing whether DunedinPACNI predicts multisystem composites of biological aging in two midlife cohorts. Replicated results indicated that less education was associated with faster DunedinPACNI in both cohorts; novel findings demonstrated that faster DunedinPACNI was associated with higher biological aging in midlife and with accelerated biological aging over 7–15 years from mid-to-later life.
Authors
- Anna L. Marsland (ORCID: https://orcid.org/0000-0001-8951-7513)
- Peter J. Gianaros (ORCID: https://orcid.org/0000-0003-2313-5277)
- Rebecca G. Reed (ORCID: https://orcid.org/0000-0003-0794-594X)
- Javier Rasero (ORCID: https://orcid.org/0000-0003-1661-2856)
- Mia K. DeCataldo (ORCID: https://orcid.org/0009-0005-6606-4327)
Institutions
- University of Pittsburgh (US)
- University of Virginia (US)
Publication Details
- Journal
- npj Aging
- Published
- 2026-11-07
- DOI
- https://doi.org/10.1038/s41514-026-00562-8
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Aging
- National Heart, Lung, and Blood Institute
- National Institute of Diabetes and Digestive and Kidney Diseases