2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guide
AIM: The "2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome" retires, replaces, and expands upon the "2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults." The primary intended audience for this guideline is clinicians who care for patients across the spectrum of cardiovascular-kidney-metabolic syndrome, an interrelated condition characterized by the interconnections among metabolic risk factors (including obesity and type 2 diabetes), chronic kidney disease, and cardiovascular disease. METHODS: A comprehensive literature search was conducted from October 29, 2024, to April 14, 2025, to identify clinical studies, systematic reviews and meta-analyses, and other evidence conducted on human subjects that were published since 2015 in English from MEDLINE (through PubMed), EMBASE, the Cochrane Library, the Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline. STRUCTURE: The focus of this clinical practice guideline is to create a living, working document that provides current knowledge in the field of cardiovascular-kidney-metabolic syndrome aimed at all practicing cardiologists, endocrinologists, nephrologists, and primary care and specialty clinicians who manage these patients.
Authors
- Debabrata Mukherjee (ORCID: https://orcid.org/0000-0002-5131-3694)
- Nosheen Reza (ORCID: https://orcid.org/0000-0002-2942-3731)
- Maria Rosa Costanzo (ORCID: https://orcid.org/0000-0001-6995-7538)
- Dave L. Dixon (ORCID: https://orcid.org/0000-0001-7560-9521)
- Daniel E. Weiner (ORCID: https://orcid.org/0000-0002-8775-394X)
- Patrick O. Gee (ORCID: https://orcid.org/0000-0001-8442-481X)
- Jane E.B. Reusch (ORCID: https://orcid.org/0000-0001-8620-1003)
- DAVID H. ELLISON
- John M. Morton (ORCID: https://orcid.org/0000-0002-9542-1283)
- Colette DeJong (ORCID: https://orcid.org/0000-0003-0514-3193)
- Lisa B. VanWagner (ORCID: https://orcid.org/0000-0002-6264-2573)
- CLAUDIA A. MERCADO
- Sripal Bangalore (ORCID: https://orcid.org/0000-0001-9485-0652)
- Cyrille K. Cornelio (ORCID: https://orcid.org/0000-0003-0499-675X)
- Sean Heffron (ORCID: https://orcid.org/0000-0002-2692-5189)
- Tiffany M. Powell‐Wiley (ORCID: https://orcid.org/0000-0001-9488-4131)
- Ian J. Neeland (ORCID: https://orcid.org/0000-0003-2831-3618)
- Lorraine S. Evangelista (ORCID: https://orcid.org/0000-0003-1708-4186)
- Goutham Rao (ORCID: https://orcid.org/0000-0001-7739-9353)
- Janani Rangaswami (ORCID: https://orcid.org/0000-0002-4313-9825)
- Amy W. Talbot
- Adam Devore
- Ian H. de Boer
- Wendy St. Peter
- Philip Schauer
- Khadijah Breathett (ORCID: https://orcid.org/0000-0001-5397-6419)
- Beverly B. Green
- Amanda R. Vest
- Tara I. Chang (ORCID: https://orcid.org/0000-0002-4691-1681)
- Nicole Bhave
- Fatima Rodriguez
- Neha Pagidipati
- Cecilia C. Low Wang
- Kevin M. Alexander
- Chiadi E. Ndumele
- Andrew H. Tran
- Sadiya S. Khan
- Shoa L. Clarke
- Madeline Sterling
- Alison L. Bailey
- Amit Khera
- Dhruv S. Kazi
- Mandeep Bajaj
- Marc P. Bonaca
- Salim S. Virani
- Anuradha Lala
- Kershaw V. Patel
- J. Bradley Starks
- Anum Saeed
- Sonali Patel
- Scott Kahan
- Katherine R. Tuttle
- Jennifer B. Green
- Biykem Bozkurt
- Katie Moegenberg
- Ildiko Lingvay
- Elif Oral
- Ambar Kulshreshtha
- Michael Miller
- Melissa Magwire
- Carl E. Orringer
Institutions
- Joint Commission (US)
- House of Representatives (NL)
- United States House of Representatives (US)
- Obesity Medicine Association (US)
- Patient Advocate Foundation (US)
Publication Details
- Journal
- Circulation
- Published
- 2026-06-09
- DOI
- https://doi.org/10.1161/cir.0000000000001453
- Citations
- 1
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 13.16