Quantifying the Effect of Seizure-Onset Zone Resection on Epilepsy Surgery Outcome
Identifying factors that determine success in epilepsy surgery is essential for improving patient selection and surgical planning. Previous studies often lack precise quantification of resection extent and rely on conventional statistics, which may be suboptimal for the small sample sizes typical of this field. We aimed to quantify how the resected fraction of the seizure-onset zone (SOZ), the clinical proxy of the epileptogenic zone, and the resection of non-SOZ tissue affect surgical outcome and to evaluate the contribution of clinical, imaging, electrophysiologic, and histopathologic factors.
Authors
- Chifaou Abdallah (ORCID: https://orcid.org/0000-0001-7232-6673)
- Jeffery A. Hall (ORCID: https://orcid.org/0000-0001-8403-8986)
- Jean Gotman (ORCID: https://orcid.org/0000-0002-9796-5946)
- Christophe Grova (ORCID: https://orcid.org/0000-0003-2775-9968)
- Birgit Frauscher (ORCID: https://orcid.org/0000-0001-6064-1529)
- Olivier Aron (ORCID: https://orcid.org/0000-0003-2620-0951)
- Nicolás von Ellenrieder (ORCID: https://orcid.org/0000-0003-0845-347X)
- Zhengchen Cai (ORCID: https://orcid.org/0000-0002-4233-5568)
- Saba Rammal
- Gang Chen (ORCID: https://orcid.org/0000-0002-2960-089X)
- John THOMAS
- Sana Hannan
- Sophie Colnat-Coulbois
- Louis G. Maillard
- Lorella Minotti
- Francois Dubeau (ORCID: https://orcid.org/0009-0005-1243-5217)
- Philippe Kahane (ORCID: https://orcid.org/0000-0003-1330-3281)
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Centre National de la Recherche Scientifique (FR)
- Concordia University (US)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Clinical Research Institute (US)
- Duke Medical Center (US)
- National Institute of Mental Health (US)
- National Institute of Mental Health (CZ)
- McGill University (CA)
- Concordia University (CA)
- Lancaster University (GB)
- Université Grenoble Alpes (FR)
- Université de Lorraine (FR)
Publication Details
- Journal
- Neurology
- Published
- 2026-06-09
- DOI
- https://doi.org/10.1212/wnl.0000000000218154
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00