Radiation dosimetry of <sup>15</sup>O-water based on dynamic large axial field of view PET.
PURPOSE: O-water based on dynamic LAFOV PET. METHODS: O-water on a Quadra LAFOV PET scanner (Siemens Healthineers) at Turku PET Centre. All organs with visual uptake over background were segmented and time-activity curves were calculated and uncorrected for decay. Time-integrated activity coefficients (TIAC) were calculated by rectangular integration followed by exponential extrapolation. The remainder of the body TIAC was calculated as the theoretical maximum TIAC minus the sum of all source organs. Organ absorbed doses were calculated using IDAC-DOSE 2.1 and effective dose was estimated according to ICRP 103. RESULTS: The highest TIACs were found in the lungs, liver and brain, whereas the highest absorbed dose was found in heart wall, spleen and kidneys. The sex-averaged effective dose coefficient was 0.62 ± 0.09 (mean ± SD) μSv/MBq. CONCLUSION: O-water is considerably lower than previously published values, amounting to an effective dose of approximately 0.25 mSv for a typical cardiac scan.
Authors
- Anna Ahlström
- Mattias Sandström (ORCID: https://orcid.org/0000-0002-5443-3122)
- Henri Kärpijoki
- J Sorensen
- Mark Lubberink
- My Jonasson (ORCID: https://orcid.org/0000-0003-3259-2613)
- Tuula Tolvanen
- Teemu Maaniitty
- Juhani Knuuti
Institutions
- Uppsala University (SE)
- Uppsala University Hospital (SE)
- University of Turku (FI)
- Turku University Hospital (FI)
- Turku PET Centre (FI)
Publication Details
- Journal
- PubMed
- Published
- 2026-06-09
- DOI
- https://doi.org/10.1016/j.nuclcard.2026.102775
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00