A modified Delphi consensus on tenosynovial giant cell tumour and giant cell tumour of bone : a report from the Birmingham Orthopaedic Oncology Meeting (BOOM).

Aims: The aim of this study was to achieve consensus on important topics related to tenosynovial giant cell tumour (TGCT) and giant cell tumour of bone (GCTB), and to identify areas for future research. Methods: In January 2026, a consensus meeting, The Birmingham Orthopaedic Oncology Meeting (BOOM), held in Cape Town, South Africa, gathered 314 delegates from 59 countries to debate 21 consensus statements on tenosynovial giant cell tumour (TGCT) and giant cell tumour of bone (GCTB) through a modified Delphi process. Results: Of the 21 statements, two achieved unanimous consensus, 18 strong consensus, and one moderate consensus. Unanimous consensus was reached for prioritizing joint-preserving intralesional curettage in GCTB when feasible, and for supporting non-surgical approaches in anatomically challenging cases, particularly sacral lesions. The statement addressing the role of denosumab in GCTB achieved only moderate consensus. The use of adjuvants in GCTB, as well as the management of recurrent and systemic GCTB, including long-term use of denosumab, reached strong consensus. Strong consensus was achieved in the surgical and non-surgical management for both primary and recurrent TGCT. Surveillance strategies for both TGCT and GCTB generated substantial discussion despite strong consensus, reflecting ongoing uncertainty and lack in evidence. Conclusion: This international consensus provides practical guidance for the management of TGCT and GCTB while identifying important gaps in evidence. Joint-preserving surgery remains central to the treatment of GCTB, with selective integration of systemic therapies and individualized surveillance. The consensus framework highlights priorities for future collaborative research in orthopaedic oncology.

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PubMed
Published
2026-06-09
DOI
https://doi.org/10.1302/0301-620x.108b.bjj-2026-0394
Primary Topic
Musculoskeletal synovial abnormalities and treatments
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article
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article

A modified Delphi consensus on tenosynovial giant cell tumour and giant cell tumour of bone : a report from the Birmingham Orthopaedic Oncology Meeting (BOOM).

Andriandi Andriandi, Wazzan AlJuhani, Osman Emre Aycan, Chris Charoenlap et al.
PubMed
Musculoskeletal synovial abnormalities and treatments
article

A modified Delphi consensus on tenosynovial giant cell tumour and giant cell tumour of bone : a report from the Birmingham Orthopaedic Oncology Meeting (BOOM).

Andriandi Andriandi, Wazzan AlJuhani, Osman Emre Aycan, Chris Charoenlap, Jos Bramer, Liang Zhen Chang, Abdullah Alotaibi, Patricio Alfaro, Manish Agarwal, Daniel C. Allison, Guy Morris, Demiën Broekhuis, Domenico Andrea Campanacci, Lorenzo Andreani, Lee Jeys, John A. Abraham, Marthelena Acosta Marín, Buğra Alpan, Stefano Bastoni, Matthew T. Houdek, Mirka Buist, Vineet Kurisunkal, Nicolás Casales, Tessa Balach, Humaid Al Farii, María G. Carrasco, Xavier Banse, Vivek Ajit Singh, Minna Laitinen, Alessandro Bruschi, M A Clara-Altamirano, Chung Ming Chan, Caitlin Bodian, T. Akiyama, Oscar Ceballos, T. B. Budny, Adam Chrobok, Lee Bayliss, Georges Basile, Yang‐Guk Chung, Eduardo Botello, Janet Chin, Turki Althunayan, Michele Boffano, Maritz Laubscher, Dimosthenis Andreou, Ibrahim Alshaygy, Samuel Earl Broida, Janie Barry, Mohammed Almashahedi, José Antonio Calvo-Haro, Jorge Cabrolier, Dawid Ciechanowicz, Luis Aponte-Tinao, Christina Berger, Juan Barriga, Rodrigo Cardoso, Charles Baird, Justin Bird, Lester Chan, Delmer Brown, Keith Hosking, Yunus Abdul Bari, Semay Baydar, Ashley Castan, Tilmann Busse, Mohammad Hardian Basuki, Nicholas Bernthal, Peter Choong, Melanie Ardelt, Zachary Burke, Abdulrahman Bobseit, Walid Ebeid, Kate Alexander, Ajay Puri, Abdulrahman Alaseem, Motaz AlAqeel, OMAR ALDOSARI, Thomas Baad-Hansen, Matthew Broadhead, Richard Carey Smith, Thomas Hilton, Patricia Bonilla Huertas, William Aston, Odion Binitie, Selma Armas, Pietro Ruggieri, Ahmed Abood, Richard Boyle, Henrik C Bauer, Ricardo Becker, Angad Bedi, Pablo Baeza, Marcela Aguirre, Juan Fernando Chaustre Florez, Joseph Benevenia, Rishi Agarwal, Francisco Bengoa, Luis Alfonso Consuegra Guzman, Lucas Annabelle
article en

Abstract

Aims: The aim of this study was to achieve consensus on important topics related to tenosynovial giant cell tumour (TGCT) and giant cell tumour of bone (GCTB), and to identify areas for future research. Methods: In January 2026, a consensus meeting, The Birmingham Orthopaedic Oncology Meeting (BOOM), held in Cape Town, South Africa, gathered 314 delegates from 59 countries to debate 21 consensus statements on tenosynovial giant cell tumour (TGCT) and giant cell tumour of bone (GCTB) through a modified Delphi process. Results: Of the 21 statements, two achieved unanimous consensus, 18 strong consensus, and one moderate consensus. Unanimous consensus was reached for prioritizing joint-preserving intralesional curettage in GCTB when feasible, and for supporting non-surgical approaches in anatomically challenging cases, particularly sacral lesions. The statement addressing the role of denosumab in GCTB achieved only moderate consensus. The use of adjuvants in GCTB, as well as the management of recurrent and systemic GCTB, including long-term use of denosumab, reached strong consensus. Strong consensus was achieved in the surgical and non-surgical management for both primary and recurrent TGCT. Surveillance strategies for both TGCT and GCTB generated substantial discussion despite strong consensus, reflecting ongoing uncertainty and lack in evidence. Conclusion: This international consensus provides practical guidance for the management of TGCT and GCTB while identifying important gaps in evidence. Joint-preserving surgery remains central to the treatment of GCTB, with selective integration of systemic therapies and individualized surveillance. The consensus framework highlights priorities for future collaborative research in orthopaedic oncology.

PubMedVol. 108-B
Rutgers, The State University of New Jersey (US), Cedars-Sinai Medical Center (US), Mount Sinai Hospital (CA), University Malaya Medical Centre (MY), Cliniques Universitaires Saint-Luc (BE), Cleveland Clinic (US), Royal Children's Hospital (AU), Mayo Clinic (US), University Medical Center Groningen (NL), Universidad del Desarrollo (CL), The University of Texas MD Anderson Cancer Center (US), University of Padua (IT), Cairo University (EG), Jichi Medical University (JP), University of Cape Town (ZA), Chulalongkorn University (TH), University of California, Los Angeles (US), Pontificia Universidad Católica de Chile (CL), University of Health Science (KH), University of Concepción (CL), Universidad de la República de Uruguay (UY), King Saud bin Abdulaziz University for Health Sciences (SA), Johannes Gutenberg University Mainz (DE), Homi Bhabha National Institute (IN), State University of Medan (ID), Universitas Airlangga (ID), Bolivarian University of Venezuela (VE), Baghdad Medical City (IQ), Royal Prince Alfred Hospital (AU), Leiden University Medical Center (NL), Tata Memorial Hospital (IN), Helsinki University Hospital (FI), King Faisal Specialist Hospital & Research Centre (SA), King Fahd Medical City (SA), Royal Orthopaedic Hospital (GB), King Saud University (SA), Sir Charles Gairdner Hospital (AU), Groote Schuur Hospital (ZA), Aarhus University Hospital (DK), Hospital Italiano de Buenos Aires (AR), Tan Tock Seng Hospital (SG), Max Super Speciality Hospital (IN), King Abdulaziz Medical City (SA), Royal Glamorgan Hospital (GB), Royal National Orthopaedic Hospital (GB), Hôpital Maisonneuve-Rosemont (CA), Hospital General Universitario Gregorio Marañón (ES), Moffitt Cancer Center (US), Acıbadem University (TR), University of Malaya (MY), Auckland University of Technology (NZ), University of Chicago (US), Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT), Demetrix (Poland) (PL), University Medical Center of the Johannes Gutenberg University Mainz (DE), Hospital de Clínicas de Porto Alegre (BR), Hospital Universitário Pedro Ernesto (BR), Hospital Universitario de Maracaibo (VE), University Hospital Münster (DE), Istituto Ortopedico Gaetano Pini (IT), Azienda Ospedaliero-Universitaria Careggi (IT), Instituto Nacional de Cancerología (CO), Essen University Hospital (DE), Universitätsklinikum Krems (AT), Istituto Ortopedico Rizzoli (IT), Hospital Regional de Concepción (CL), Mayo Clinic in Arizona (US), Vall d'Hebron Hospital Universitari (ES), Sağlık Bilimleri Üniversitesi (TR), Clinica Santa Maria (CL), King Khalid University Hospital (SA), Fundación Arturo López Pérez (CL), Sultan Qaboos University Hospital (OM), National University Hospital (SG), Mayo Clinic in Florida (US), Amsterdam University Medical Centers (NL), Hospital del Niño (PA), Instituto Nacional de Cancerología (MX), Capital Health (US), The Catholic University of Korea Seoul St. Mary's Hospital (KR), Australasian Sarcoma Study Group (AU), Azienda Ospedaliera Universitaria Pisana (IT), Jichi Medical University Saitama Medical Center (JP), Rutgers New Jersey Medical School (US), University of Florence (IT), University College London (GB), Pomeranian Medical University (PL), University of California, Davis (US), Catholic University of Korea (KR), University of Health Sciences Antigua (AG), University of Gothenburg (SE), University of Amsterdam (NL)
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Musculoskeletal synovial abnormalities and treatments
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