A blueberry-derived polysaccharide inhibits SARS-CoV-2 papain-like protease and exhibits broad-spectrum anti-coronavirus activity

. At the cellular level, 2B4 displayed excellent safety and dose-dependent inhibition of HCoV-OC43 replication. This work offers a new perspective and experimental foundation for the development of natural antiviral candidates from edible and medicinal plants.

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Publication Details

Journal
Natural Product Research
Published
2026-06-09
DOI
https://doi.org/10.1080/14786419.2026.2683708
Primary Topic
Polysaccharides and Plant Cell Walls
Type
article
Field-Weighted Citation Impact
0.00
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article

A blueberry-derived polysaccharide inhibits SARS-CoV-2 papain-like protease and exhibits broad-spectrum anti-coronavirus activity

G.-F. Chen, Shufen Song, Chenxin Zhang, Can Jin et al.
Natural Product Research
Polysaccharides and Plant Cell Walls
article

A blueberry-derived polysaccharide inhibits SARS-CoV-2 papain-like protease and exhibits broad-spectrum anti-coronavirus activity

G.-F. Chen, Shufen Song, Chenxin Zhang, Can Jin, Shizhao Chen, Jia Li, Kan Ding, Bo Feng, Xuejing Liu
article en

Abstract

. At the cellular level, 2B4 displayed excellent safety and dose-dependent inhibition of HCoV-OC43 replication. This work offers a new perspective and experimental foundation for the development of natural antiviral candidates from edible and medicinal plants.

Natural Product Research
Nanjing University of Chinese Medicine (CN), Chinese Academy of Sciences (CN), Wuhan Institute of Virology (CN), Shanghai Institute of Materia Medica (CN), University of Chinese Academy of Sciences (CN)
Good health and well-being
Openalex Percentile: Top 8%
Polysaccharides and Plant Cell Walls
DOISourceOpenAlex
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A blueberry-derived polysaccharide inhibits SARS-CoV-2 papain-like protease and exhibits broad-spectrum anti-coronavirus activity — G.-F. Chen, Shufen Song, et al. · Natural Product Research (2026) | TGRS Research Map | TGRS