AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for ependymomas

Ependymomas are uncommon primary tumors of the central nervous system (CNS) that affect both children and adults. In recent years, molecular analyses have identified multiple subtypes of ependymal tumors based on location, patterns of CpG island methylation, and gene fusion events. While this knowledge is highly important in progressing diagnostic precision, prognostication, and effective treatments, an unwanted side effect is that best practice diagnostics are often inaccessible because of cost and technical barriers for many low- or lower middle-income countries. The ADAPTR group (Adapting Diagnostic Approaches for Practical Taxonomy in Resource-Restrained Regions) is an initiative of the Asian Oceanian Society of Neuropathology and aims to provide practical guidelines for CNS tumor diagnostics at various levels of pathology resource restrictions. In this manuscript, we propose a practical approach to the diagnosis of ependymal tumors based on ADAPTR resource levels. These recommendations provide a practical adaptation of World Health Organisation Classification of Tumours of the Central Nervous System guidelines suited to routine diagnosis in resource-restrained regions.

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Publication Details

Journal
Brain Pathology
Published
2026-06-09
DOI
https://doi.org/10.1111/bpa.70114
Primary Topic
Glioma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for ependymomas

Maysa A. Al-Hussaini, Junji Shibahara, David N. Louis, Laveniya Satgunaseelan et al.
Brain Pathology
Glioma Diagnosis and Treatment
article

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for ependymomas

Maysa A. Al-Hussaini, Junji Shibahara, David N. Louis, Laveniya Satgunaseelan, Vani Santosh, Sung‐Hye Park, Kenta Masui, Tarık Tihan, Chitra Sarkar, Ho‐Keung Ng, Takashi Komori, Pieter Wesseling, Geeta Chacko, Michael E. Buckland
article en

Abstract

Ependymomas are uncommon primary tumors of the central nervous system (CNS) that affect both children and adults. In recent years, molecular analyses have identified multiple subtypes of ependymal tumors based on location, patterns of CpG island methylation, and gene fusion events. While this knowledge is highly important in progressing diagnostic precision, prognostication, and effective treatments, an unwanted side effect is that best practice diagnostics are often inaccessible because of cost and technical barriers for many low- or lower middle-income countries. The ADAPTR group (Adapting Diagnostic Approaches for Practical Taxonomy in Resource-Restrained Regions) is an initiative of the Asian Oceanian Society of Neuropathology and aims to provide practical guidelines for CNS tumor diagnostics at various levels of pathology resource restrictions. In this manuscript, we propose a practical approach to the diagnosis of ependymal tumors based on ADAPTR resource levels. These recommendations provide a practical adaptation of World Health Organisation Classification of Tumours of the Central Nervous System guidelines suited to routine diagnosis in resource-restrained regions.

Brain Pathology
Brigham and Women's Hospital (US), The University of Sydney (AU), University of Nagasaki (JP), Harvard University (US), University of Miami (US), Christian Medical College, Vellore (IN), Chinese University of Hong Kong (HK), Kyorin University (JP), King Hussein Cancer Center (JO), Royal Prince Alfred Hospital (AU), New Generation University College (ET), Massachusetts General Hospital (US), Tokyo Metropolitan Neurological Hospital (JP), Princess Máxima Center (NL), Amsterdam University Medical Centers (NL), Nagasaki University (JP), All India Institute of Medical Sciences (IN), National Institute of Mental Health and Neurosciences (IN)
Openalex Percentile: Top 8%
Glioma Diagnosis and Treatment
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