Activation of a Silent Type II PKS Pathway in <i>Streptomyces avermitilis</i> via a Reintroduction Strategy
values of 27.23 ± 1.69 μM and 61.65 ± 1.37 μM, respectively. Overall, this work validates that reintroduction of endogenous BGCs represents a robust genome mining approach to activate silent metabolic pathways and accelerate the discovery of bioactive novel natural products.
Authors
- Chunshuai Huang (ORCID: https://orcid.org/0000-0002-3126-2340)
- Guangtao Zhang (ORCID: https://orcid.org/0000-0002-4396-5975)
- Z H Zhang
- Tengfei Zhao
- Jinfen Yuan
- Shaofei Wang
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Yantai University (CN)
- Chinese Academy of Sciences (CN)
- Anhui University of Traditional Chinese Medicine (CN)
- Shanghai Institute of Materia Medica (CN)
- Advanced Research Institute (US)
- Thai Health Promotion Foundation (TH)
- Shandong Academy of Pharmaceutical Sciences (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2026-06-09
- DOI
- https://doi.org/10.1021/acs.jnatprod.6c00382
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Natural Science Foundation of Shandong Province
- Taishan Scholar Project of Shandong Province
- Key Technology Research and Development Program of Shandong