Abnormal B-Cell Exosome Proapoptotic and Antiapoptotic Cargo in Multiple Sclerosis
Compartmentalized CNS inflammation involving B cells is implicated in gray matter injury and disease progression in multiple sclerosis (MS). Products secreted by B cells of patients with MS can kill oligodendrocytes and neurons, a cytotoxicity conferred by their exosome-enriched extracellular vesicle (Ex En) fraction.
Authors
- Mihir Kakara (ORCID: https://orcid.org/0000-0001-8951-8604)
- Simon Thébault (ORCID: https://orcid.org/0000-0002-8881-4521)
- Hanane Touil (ORCID: https://orcid.org/0000-0002-9601-4364)
- Paul M. Stemmer (ORCID: https://orcid.org/0000-0003-3315-9846)
- Liljana Nedelkoska
- Gautier Bréville (ORCID: https://orcid.org/0000-0003-0890-1981)
- Amit Bar‐Or (ORCID: https://orcid.org/0000-0001-7179-0335)
- Luana D. Yamashita (ORCID: https://orcid.org/0009-0008-8402-5040)
- Yeseul Kim (ORCID: https://orcid.org/0000-0003-0738-5508)
- Ayman Rezk
- Celine Delucinge-Vivier (ORCID: https://orcid.org/0009-0003-1172-0695)
- Nicole Doyon-Reale
- Samuel Weissman
- Robert P. Lisak (ORCID: https://orcid.org/0000-0001-7638-1696)
- Leah Zuroff
- Diego A. Espinoza (ORCID: https://orcid.org/0000-0002-9627-6508)
- Joyce A. Benjamins
Institutions
- University of Geneva (CH)
- Montreal Neurological Institute and Hospital (CA)
- Children's Hospital of Philadelphia (US)
- University of California, San Francisco (US)
- Wayne State University (US)
- McGill University Health Centre (CA)
- Institute of Neuroimmunology of the Slovak Academy of Sciences (SK)
- New York University (US)
- University of Pennsylvania (US)
- Philadelphia University (US)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2026-06-09
- DOI
- https://doi.org/10.1212/nxi.0000000000200590
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00