Revisiting Hydrazine Moiety as a Scaffold for the Synthesis of Potential Antiviral Pyrazole Ribonucleoside Analogues
Pyrazole ribonucleoside analogues were prepared via a linear approach starting with the reaction of D-ribosylhydrazine with 1,3-dicarbonyl or acrylonitrile derivatives, thereby avoiding the regio- and stereoselectivity challenges typically encountered in N-glycosylation reactions. Three series of pyrazole nucleoside analogues, as along with selected corresponding pronucleotides, were prepared and their antiviral activity against Zika virus and Sars-Cov-2 is reported.
Authors
- Jean‐Jacques Vasseur (ORCID: https://orcid.org/0000-0002-4379-6139)
- Michaël Smietana (ORCID: https://orcid.org/0000-0001-8132-7221)
- Suzanne Peyrottes (ORCID: https://orcid.org/0000-0003-1705-0576)
- Christophe Mathé (ORCID: https://orcid.org/0000-0003-3114-9361)
- Anaïs Guillou
- Delphine Muriaux
- Nathalie Gros
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Montpellier (FR)
- Centre d’Etudes Politiques Et sociaLes (FR)
- Institut des Biomolécules Max Mousseron (FR)
Publication Details
- Journal
- ChemMedChem
- Published
- 2026-06-08
- DOI
- https://doi.org/10.1002/cmdc.70326
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00