Metformin attenuates valproic acid–induced developmental cardiotoxicity through activation of the AMPK/PGC-1α axis and restoration of mitochondrial and redox homeostasis in zebrafish embryos
, mitochondrial, and antioxidant capacity by MET suggests that the AMPK/PGC-1α axis may serve as a central target in VPA cardiotoxicity.
Authors
- Ünsal Veli Üstündağ (ORCID: https://orcid.org/0000-0003-0804-1475)
- Fümet Duygu Üstündağ (ORCID: https://orcid.org/0000-0001-5290-8924)
- Neşe Ayşit (ORCID: https://orcid.org/0000-0002-4243-9092)
Institutions
- Ağrı İbrahim Çeçen University (TR)
- Istanbul Medipol University (TR)
Publication Details
- Journal
- Drug and Chemical Toxicology
- Published
- 2026-06-08
- DOI
- https://doi.org/10.1080/01480545.2026.2684476
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00