FROM COCRYSTAL DESIGN TO DRUG SHELF: NOVEL PREPARATION METHODS AND MARKETED PHARMACEUTICAL PRODUCTS

Abstract: A possible technique to increase the solubility of BCS Classes II & IV medicationsthat are poorly soluble is pharmaceutical cocrystallization. The benefits of cocrystallization onthe stability and rate of medication dissolution are not well known to most scientists. Evidencewas compiled from a range of articles utilizing Medline, Pubmed, Embase, Scopus, GoogleScholar, and Web of Science in an organised and succinct manner. This paper addressescocrystallization technology, products that have been marketed using this strategy, and problemsassociated with these processes. The most popular and successful method for cocrystal synthesisis laser irradiation. Other novelistic or contemporary methods for producing cocrystals includehot melt extrusion, spray evaporation, super critical fluid dynamic technology, and irradiation.The several in-vitro assessment parameters used to assess the cocrystals and their drug releaseare also included in this publication. It also explains the numerous innovative and conventionalmethods of producing medicinal cocrystals, as well as the reasons behind the interest ofresearchers and the pharmaceutical industry in cocrystals. Pharmaceutical crystals are currentlythought to be critically needed for medical or scientific purposes. The countless reviews andresearch articles that have been published in various periodicals over the past 10 years clearlydemonstrate this. In recent years, a number of pharmaceutical companies have begun assertingpatents worldwide. These companies are growing rapidly because of the laws and the link tointellectual property. Pharmaceutical crystals are an essential and useful tool for raising thestability, melting point, and bioavailability of medications.