Expression of Concern: ING5 is phosphorylated by CDK2 and controls cell proliferation independently of p53

Expression of Concern: ING5 is phosphorylated by CDK2 and controls cell proliferation independently of p53 The PLOS One Editors After this article [1] was published, several concerns were raised.Specifically, • The shING5-1 and shING5-2 panels in Fig 6B appear to overlap.• Figs 5-7 report the results of statistical analyses, however the article [1] does not describe the statistical tests used.• The original quantitative data underlying the figures have not been provided, contrary to the Data Availability statement.Co-corresponding author JV provided an updated version of Fig 6 with replacement images for all panels in Fig 6B from replicate experiments conducted at the time of the original experiments.The quantified data from Fig 6B presented in Fig 6C are updated to include the replacement panels in the updated Fig 6B, such that the updated Fig 6C shows the mean and standard deviation of four measurements.With the updated Fig 6, PLOS considers this concern resolved.Regarding the statistical methodology used in [1], co-corresponding author JV stated that they were unable to identify the statistical analyses used in this article.As the statistical methods used cannot be confirmed, the PLOS One Editors advise readers to interpret the statistical results in Fig 5 and 7 with caution.Co-corresponding author JV provided the data underlying Figs 1 and 4, and partial underlying data for Figs 2-3 and 5-7 (S1-S9 Files).They stated the remainder of the underlying data are no longer available.As

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Publication Details

Journal
PLoS ONE
Published
2026-06-09
DOI
https://doi.org/10.1371/journal.pone.0351194
Primary Topic
Cancer-related Molecular Pathways
Type
article
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0.00
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article

Expression of Concern: ING5 is phosphorylated by CDK2 and controls cell proliferation independently of p53

The PLOS Computational Biology Editors
PLoS ONE
Cancer-related Molecular Pathways
article

Expression of Concern: ING5 is phosphorylated by CDK2 and controls cell proliferation independently of p53

The PLOS Computational Biology Editors
article en

Abstract

Expression of Concern: ING5 is phosphorylated by CDK2 and controls cell proliferation independently of p53 The PLOS One Editors After this article [1] was published, several concerns were raised.Specifically, • The shING5-1 and shING5-2 panels in Fig 6B appear to overlap.• Figs 5-7 report the results of statistical analyses, however the article [1] does not describe the statistical tests used.• The original quantitative data underlying the figures have not been provided, contrary to the Data Availability statement.Co-corresponding author JV provided an updated version of Fig 6 with replacement images for all panels in Fig 6B from replicate experiments conducted at the time of the original experiments.The quantified data from Fig 6B presented in Fig 6C are updated to include the replacement panels in the updated Fig 6B, such that the updated Fig 6C shows the mean and standard deviation of four measurements.With the updated Fig 6, PLOS considers this concern resolved.Regarding the statistical methodology used in [1], co-corresponding author JV stated that they were unable to identify the statistical analyses used in this article.As the statistical methods used cannot be confirmed, the PLOS One Editors advise readers to interpret the statistical results in Fig 5 and 7 with caution.Co-corresponding author JV provided the data underlying Figs 1 and 4, and partial underlying data for Figs 2-3 and 5-7 (S1-S9 Files).They stated the remainder of the underlying data are no longer available.As

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Cancer-related Molecular Pathways
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Expression of Concern: ING5 is phosphorylated by CDK2 and controls cell proliferation independently of p53 — The PLOS Computational Biology Editors · PLoS ONE (2026) | TGRS Research Map | TGRS