PROTEUS May Mean New SOC for Some Prostate Cancers

For people with localized, high-risk prostate cancer, treatment with 6 months of apalutamide and androgen deprivation therapy (ADT) both before and after surgery reduces the risk of metastases and death compared with perioperative ADT alone, according to results of the phase III PROTEUS trial. At 5 years, 78.2% of patients who received apalutamide plus ADT were alive and free from metastasis, compared with 73.5% in the ADT only group.

Publication Details

Journal
Cancer Discovery
Published
2026-06-09
DOI
https://doi.org/10.1158/2159-8290.cd-nw2026-0068
Primary Topic
Prostate Cancer Treatment and Research
Type
article
Field-Weighted Citation Impact
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article

PROTEUS May Mean New SOC for Some Prostate Cancers

Cancer Discovery
Prostate Cancer Treatment and Research
article

PROTEUS May Mean New SOC for Some Prostate Cancers

article en

Abstract

For people with localized, high-risk prostate cancer, treatment with 6 months of apalutamide and androgen deprivation therapy (ADT) both before and after surgery reduces the risk of metastases and death compared with perioperative ADT alone, according to results of the phase III PROTEUS trial. At 5 years, 78.2% of patients who received apalutamide plus ADT were alive and free from metastasis, compared with 73.5% in the ADT only group.

Cancer Discovery
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Openalex Percentile: Top 7%
Prostate Cancer Treatment and Research
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PROTEUS May Mean New SOC for Some Prostate Cancers · Cancer Discovery (2026) | TGRS Research Map | TGRS