Cutaneous Tuberculosis Presenting as Rhino-Facial Nodular Swelling

Cutaneous tuberculosis is an uncommon manifestation of Mycobacterium tuberculosis infection and may present diverse and atypical clinical features, often resulting in diagnostic delay. The case of a 72-year-old woman who presented with a gradually progressive nodular swelling on the left side of her nose, associated with epiphora, is reported in the present study. A clinical examination revealed a firm rhino-facial nodular lesion with ipsilateral nasolacrimal duct obstruction. Initial investigations were inconclusive, and the Mantoux test result was negative. Repeat histopathology revealed epithelioid granulomas with multinucleated giant cells consistent with granulomatous dermatitis. A cutaneous tuberculosis-specific assay result was positive, in conjunction with clinicopathological findings, which supported the diagnosis of an atypical nodular type of lupus vulgaris. The patient showed marked clinical improvement after the initiation of standard antitubercular therapy. This case highlights the diagnostic challenges posed by atypical facial lupus vulgaris and underscores the importance of clinicopathological correlation, with adjunctive use of immunological assays when conventional investigations are inconclusive, particularly in tuberculosis-endemic regions.

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Publication Details

Journal
American Journal of Tropical Medicine and Hygiene
Published
2026-06-09
DOI
https://doi.org/10.4269/ajtmh.26-0177
Primary Topic
Infectious Diseases and Tuberculosis
Type
article
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article

Cutaneous Tuberculosis Presenting as Rhino-Facial Nodular Swelling

Malathi Munisamy, Deepti Singh, Sheetanshu Kumar, Arun Somasundaram et al.
American Journal of Tropical Medicine and Hygiene
Infectious Diseases and Tuberculosis
article

Cutaneous Tuberculosis Presenting as Rhino-Facial Nodular Swelling

Malathi Munisamy, Deepti Singh, Sheetanshu Kumar, Arun Somasundaram, Karthik Lakshmi Narayanan, Gurumurthy Balasubramanian, Sanjay Sriram
article en

Abstract

Cutaneous tuberculosis is an uncommon manifestation of Mycobacterium tuberculosis infection and may present diverse and atypical clinical features, often resulting in diagnostic delay. The case of a 72-year-old woman who presented with a gradually progressive nodular swelling on the left side of her nose, associated with epiphora, is reported in the present study. A clinical examination revealed a firm rhino-facial nodular lesion with ipsilateral nasolacrimal duct obstruction. Initial investigations were inconclusive, and the Mantoux test result was negative. Repeat histopathology revealed epithelioid granulomas with multinucleated giant cells consistent with granulomatous dermatitis. A cutaneous tuberculosis-specific assay result was positive, in conjunction with clinicopathological findings, which supported the diagnosis of an atypical nodular type of lupus vulgaris. The patient showed marked clinical improvement after the initiation of standard antitubercular therapy. This case highlights the diagnostic challenges posed by atypical facial lupus vulgaris and underscores the importance of clinicopathological correlation, with adjunctive use of immunological assays when conventional investigations are inconclusive, particularly in tuberculosis-endemic regions.

American Journal of Tropical Medicine and Hygiene
Jawaharlal Institute of Post Graduate Medical Education and Research (IN)
Good health and well-being
Openalex Percentile: Top 6%
Infectious Diseases and Tuberculosis
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Cutaneous Tuberculosis Presenting as Rhino-Facial Nodular Swelling — Malathi Munisamy, Deepti Singh, et al. · American Journal of Tropical Medicine and Hygiene (2026) | TGRS Research Map | TGRS