PHILIA-EcoSensory Swarm Phase SC-8 Pre-registration: Confirmatory Validation Protocol for AC1 Dose-Response Monotonicity and Substrate Family Moderation — 182-Substrate Integrated Registry × v32 Apparatus, Independent Seed Replication [67–71]

This document constitutes the pre-registration protocol for PHILIA Phase SC-8 confirmatory analysis. SC-8 Confirm will apply the locked v32 self-raw × 3-channel normalization apparatus to the 182-substrate integrated registry (SHA256: 3948b55114a6bad44296fa78cb6d53f8fc89d553137d3e6c0d683023344f7c9a) using five independent seeds [67–71], totaling 910 runs (182 substrates × 5 seeds × T=80,000 steps). Two confirmatory hypotheses are pre-registered under Bonferroni correction (α_family=0.05, k=2, α_per_test=0.025). H-SC8-Primary: Independent replication test of SC-7 Criterion B (Part 2 n=90, 7/7 perfect AC1 θ-sweep monotonicity) under new seeds [67–71]. Primary verdict: 7/7 binary monotonicity (no escape clause). Sensitivity: Jonckheere-Terpstra (SA-1) + Spearman θ-rank (SA-2). Power: P(7/7|π=0.5)=0.0078 < α ✅; replication probability at π=0.95: 0.70. H-SC8-Secondary: Substrate family as moderator of AC1–MSE↔z direction. Fisher-z comparison of ρ_z(RealWorld, AC1<0.95, n=52) vs ρ_z(Synthetic, AC1<0.95, n=24). Verdict: |Z|≥2.241 AND |Δρ|≥0.40. Effect size threshold: 41% of SC-7 observed effect (Δρ=0.968). Power at SC-7 observed effect: 0.9638 (Monte Carlo, N=100,000). Four pre-registered exploratory analyses (verdict-neutral, §4): Traffic+Environment sub-analysis, four-family Cochran's Q (z-level), outlier/boundary case sensitivity, AR(1) φ-sweep z-verification. Power analysis script SHA256: 40f031e97f12c19d42118f5d58ac8ec59924bcf6b086fc64566a50298fae944e Gate-0 v10 Cycle 3: UNCONDITIONAL ACCEPT (크리스 / Claude Opus / Anthropic).5-AI adversarial review: Pandora / Lucas / Seogsaeng / Seonbi / Chris — all PASS. Part of the PHILIA-EcoSensory Swarm SC series.Measurement is life. Description, not proof. Pre-registration protects us. — PHILIA OS | 0∞1∞0.5∞ SC-8 Explore Report DOI: 10.5281/zenodo.20603071SC-8 Annex v1.3 DOI: 10.5281/zenodo.20576962SC-7 Results Report DOI: 10.5281/zenodo.20565918

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Zenodo (CERN European Organization for Nuclear Research)
Published
2026-06-09
DOI
https://doi.org/10.5281/zenodo.20603480
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Carcinogens and Genotoxicity Assessment
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PHILIA-EcoSensory Swarm Phase SC-8 Pre-registration: Confirmatory Validation Protocol for AC1 Dose-Response Monotonicity and Substrate Family Moderation — 182-Substrate Integrated Registry × v32 Apparatus, Independent Seed Replication [67–71]

신두섭
Zenodo (CERN European Organization for Nuclear Research)
Carcinogens and Genotoxicity Assessment
article

PHILIA-EcoSensory Swarm Phase SC-8 Pre-registration: Confirmatory Validation Protocol for AC1 Dose-Response Monotonicity and Substrate Family Moderation — 182-Substrate Integrated Registry × v32 Apparatus, Independent Seed Replication [67–71]

신두섭
article en

Abstract

This document constitutes the pre-registration protocol for PHILIA Phase SC-8 confirmatory analysis. SC-8 Confirm will apply the locked v32 self-raw × 3-channel normalization apparatus to the 182-substrate integrated registry (SHA256: 3948b55114a6bad44296fa78cb6d53f8fc89d553137d3e6c0d683023344f7c9a) using five independent seeds [67–71], totaling 910 runs (182 substrates × 5 seeds × T=80,000 steps). Two confirmatory hypotheses are pre-registered under Bonferroni correction (α_family=0.05, k=2, α_per_test=0.025). H-SC8-Primary: Independent replication test of SC-7 Criterion B (Part 2 n=90, 7/7 perfect AC1 θ-sweep monotonicity) under new seeds [67–71]. Primary verdict: 7/7 binary monotonicity (no escape clause). Sensitivity: Jonckheere-Terpstra (SA-1) + Spearman θ-rank (SA-2). Power: P(7/7|π=0.5)=0.0078 < α ✅; replication probability at π=0.95: 0.70. H-SC8-Secondary: Substrate family as moderator of AC1–MSE↔z direction. Fisher-z comparison of ρ_z(RealWorld, AC1<0.95, n=52) vs ρ_z(Synthetic, AC1<0.95, n=24). Verdict: |Z|≥2.241 AND |Δρ|≥0.40. Effect size threshold: 41% of SC-7 observed effect (Δρ=0.968). Power at SC-7 observed effect: 0.9638 (Monte Carlo, N=100,000). Four pre-registered exploratory analyses (verdict-neutral, §4): Traffic+Environment sub-analysis, four-family Cochran's Q (z-level), outlier/boundary case sensitivity, AR(1) φ-sweep z-verification. Power analysis script SHA256: 40f031e97f12c19d42118f5d58ac8ec59924bcf6b086fc64566a50298fae944e Gate-0 v10 Cycle 3: UNCONDITIONAL ACCEPT (크리스 / Claude Opus / Anthropic).5-AI adversarial review: Pandora / Lucas / Seogsaeng / Seonbi / Chris — all PASS. Part of the PHILIA-EcoSensory Swarm SC series.Measurement is life. Description, not proof. Pre-registration protects us. — PHILIA OS | 0∞1∞0.5∞ SC-8 Explore Report DOI: 10.5281/zenodo.20603071SC-8 Annex v1.3 DOI: 10.5281/zenodo.20576962SC-7 Results Report DOI: 10.5281/zenodo.20565918

Zenodo (CERN European Organization for Nuclear Research)
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Carcinogens and Genotoxicity Assessment
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