Light-Driven Iron-Mediated Thiotrifluoromethylation of Alkenes Using CF <sub>3</sub> CO <sub>2</sub> H
-aryl benzenesulfonothioates as arylthio donors. Under purple-light irradiation, simple iron(III) salts enable a three-component reaction that affords diverse aryl 3,3,3-trifluoropropyl sulfides with broad scope and good functional group tolerance. The products are readily elaborated and applied to late-stage modification of complex molecules, providing a simple and scalable route to fluorinated sulfur-containing scaffolds.
Authors
- Chi Wai Cheung (ORCID: https://orcid.org/0000-0003-4415-0767)
- Jun‐An Ma (ORCID: https://orcid.org/0000-0002-3902-6799)
- Ting Zhou (ORCID: https://orcid.org/0000-0002-8475-5798)
- Yinghui Zhou (ORCID: https://orcid.org/0009-0006-7249-5331)
Institutions
- Tianjin University (CN)
- Chinese University of Hong Kong (HK)
- State Key Laboratory of Synthetic Chemistry (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-06-09
- DOI
- https://doi.org/10.1021/acs.orglett.6c02069
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese University of Hong Kong
- National Key Research and Development Program of China