Triarylborane-Promoted Cyano-Mukaiyama Aldol Reaction Involving a 1,5-Metalate Shift
plays a dual role in the transformation: it functions as a Lewis acid to activate the cyano group, initiating the Mukaiyama aldol addition, and also serves as a coordination bridge that links the iminium intermediate with the aryl donor through the formation of an "ate" complex, thereby facilitating the subsequent 1,5-metalate shift.
Authors
- Yuanhong Liu (ORCID: https://orcid.org/0000-0003-1153-5695)
- Meijun Xiong
- Hongliang Zhao
- Zhongxian Li (ORCID: https://orcid.org/0000-0003-4838-5045)
- Qing Han
- Xin Xie
Institutions
- Chinese Academy of Sciences (CN)
- Zhengzhou University (CN)
- Henan Academy of Sciences (CN)
- Shanghai Institute of Organic Chemistry (CN)
- New Technology (Israel) (IL)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-06-08
- DOI
- https://doi.org/10.1021/acs.orglett.6c02068
- Primary Topic
- Organoboron and organosilicon chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Henan Province