DISSEMINATED INTRAVASCULAR COAGULATION SYNDROME: THE MODERN PARADIGM OF PATHOPHYSIOLOGY, EARLY DIAGNOSIS, AND PERSONALIZED THERAPY

Disseminated intravascular coagulation (DIC) syndrome remains a critical problem in modern medicine, characterized by systemic activation of coagulation, impaired fibrinolysis, and endothelial dysfunction. Despite significant advances in understanding its molecular mechanisms, mortality associated with DIC remains unacceptably high (up to 78% in critical conditions). This article provides an indepth review of current scientific concepts regarding DIC, including the new 2025 phase classification, strategies for early diagnosis at preclinical stages, and the role of a personalized approach in patient management. Methodology: Statistical analysis included 50 scientific publications from the last five years concerning DIC syndrome following surgical procedures, trauma of various etiologies, and sepsis.