ACUTE ANTICOAGULANT AND FIBRINOLYTIC EFFECTS OF AN AQUEOUS EXTRACT OF ALAI MUMIYO IN A CANINE MODEL

This research investigated how a water-based (aqueous) extract of Alai mumiyo affects blood clotting parameters in a canine model, testing ten healthy adult dogs weighing 12–18 kg that were given a 50 mg/kg body weight oral dose. To accurately map the short-term response, blood samples were gathered at baseline before the treatment, as well as at 30 minutes and 60 minutes post-administration. The data showed that the Alai mumiyo extract drastically slowed down the body's clotting mechanisms, triggering a pronounced lengthening of total blood clotting time, plasma recalcification time, and thrombin time, while also causing a major increase in plasma tolerance to heparin. Meanwhile, total fibrinogen concentrations dropped slightly but not enough to be statistically significant, whereas the body's natural clot-dissolving (fibrinolytic) activity saw a moderate increase. Crucially, total plasma protein concentrations remained entirely unchanged throughout the hour-long window, confirming that the blood did not simply become diluted. Together, these metrics prove that Alai mumiyo functions as an effective, rapid-acting natural anticoagulant, achieving its results by simultaneously influencing the coagulation cascade and the fibrin-clearing pathways. Ultimately, these results highlight the therapeutic potential of Alai mumiyo as a natural anti-clotting or antithrombotic agent for medical applications.