Clockwork symbiosis: The vital interplay of microbiota and human chronobiology

{"The":[0,83],"human":[1,74,93,216],"microbiota":[2,118],"and":[3,17,30,34,59,68,76,94,105,116,122,128,142,166,176,210],"host":[4,106,167],"circadian":[5,134],"system":[6],"engage":[7],"in":[8,100,158],"a":[9],"bidirectional":[10],"dialogue":[11],"with":[12,70,79,138],"consequences":[13],"for":[14,44,63,90,112,188],"metabolism,":[15],"immunity,":[16],"barrier":[18],"physiology.":[19],"This":[20],"narrative":[21],"review":[22],"examines":[23],"the":[24,28,36,87,132],"microbiota-chronobiology":[25],"interface":[26],"across":[27],"gut":[29,88],"selected":[31],"extra-intestinal":[32],"niches":[33],"uses":[35],"term":[37],"\\"clockwork":[38],"symbiosis\\"":[39],"as":[40,126,206],"an":[41],"organizing":[42],"framework":[43],"this":[45],"crosstalk.":[46],"A":[47],"structured,":[48],"non-exhaustive":[49],"search":[50],"of":[51,55],"PubMed,":[52],"Scopus,":[53],"Web":[54],"Science,":[56],"Cochrane":[57],"Library,":[58],"Embase":[60],"was":[61],"conducted":[62],"studies":[64,78,96],"published":[65],"between":[66],"2000":[67],"2024,":[69],"priority":[71],"given":[72],"to":[73,153,183],"evidence":[75,85,111,187],"mechanistic":[77,181],"clear":[80],"translational":[81],"relevance.":[82],"strongest":[84],"concerns":[86],"microbiota,":[89],"which":[91],"both":[92],"preclinical":[95],"support":[97],"diurnal":[98],"variation":[99],"microbial":[101,140],"composition,":[102],"metabolite":[103],"production,":[104],"metabolic":[107,144],"signaling.":[108],"By":[109],"contrast,":[110],"vaginal,":[113],"oral,":[114],"skin,":[115],"respiratory":[117],"remains":[119,192],"comparatively":[120],"limited":[121],"is":[123,136,150],"best":[124],"treated":[125],"emerging":[127],"largely":[129],"hypothesis-generating.":[130],"Across":[131],"literature,":[133],"disruption":[135],"associated":[137],"altered":[139],"rhythmicity":[141],"adverse":[143],"or":[145],"inflammatory":[146],"phenotypes,":[147],"but":[148,202],"causality":[149],"often":[151],"difficult":[152],"isolate":[154],"from":[155],"co-occurring":[156],"changes":[157],"diet,":[159],"sleep,":[160],"stress,":[161],"light":[162],"exposure,":[163],"medication":[164],"use,":[165],"disease":[168],"state.":[169],"Microbiota-derived":[170],"metabolites,":[171],"particularly":[172],"short-chain":[173],"fatty":[174],"acids":[175],"bile-acid":[177],"derivatives,":[178],"provide":[179],"plausible":[180],"links":[182],"peripheral":[184],"clocks,":[185],"although":[186],"direct":[189],"clinical":[190,203],"manipulation":[191],"preliminary.":[193],"Overall,":[194],"preserving":[195],"host-microbiota":[196],"temporal":[197],"alignment":[198],"appears":[199],"biologically":[200],"important,":[201],"applications":[204],"such":[205],"chrononutrition,":[207],"timed":[208],"biotics,":[209],"chronotherapy":[211],"still":[212],"require":[213],"rigorous":[214],"time-standardized":[215],"studies.":[217]}

Authors

Institutions

Publication Details

Journal
Chronobiology International
Published
2026-06-03
DOI
https://doi.org/10.1080/07420528.2026.2682478
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
article

Clockwork symbiosis: The vital interplay of microbiota and human chronobiology

F. Boubaker, Ichrak Dridi, Anis Chabbou, Omkolthoum Sallem
Chronobiology International
Gut microbiota and health
article

Clockwork symbiosis: The vital interplay of microbiota and human chronobiology

F. Boubaker, Ichrak Dridi, Anis Chabbou, Omkolthoum Sallem
article en

Abstract

The human microbiota and host circadian system engage in a bidirectional dialogue with consequences for metabolism, immunity, and barrier physiology. This narrative review examines the microbiota-chronobiology interface across the gut and selected extra-intestinal niches and uses the term "clockwork symbiosis" as an organizing framework for this crosstalk. A structured, non-exhaustive search of PubMed, Scopus, Web of Science, Cochrane Library, and Embase was conducted for studies published between 2000 and 2024, with priority given to human evidence and mechanistic studies with clear translational relevance. The strongest evidence concerns the gut microbiota, for which both human and preclinical studies support diurnal variation in microbial composition, metabolite production, and host metabolic signaling. By contrast, evidence for vaginal, oral, skin, and respiratory microbiota remains comparatively limited and is best treated as emerging and largely hypothesis-generating. Across the literature, circadian disruption is associated with altered microbial rhythmicity and adverse metabolic or inflammatory phenotypes, but causality is often difficult to isolate from co-occurring changes in diet, sleep, stress, light exposure, medication use, and host disease state. Microbiota-derived metabolites, particularly short-chain fatty acids and bile-acid derivatives, provide plausible mechanistic links to peripheral clocks, although evidence for direct clinical manipulation remains preliminary. Overall, preserving host-microbiota temporal alignment appears biologically important, but clinical applications such as chrononutrition, timed biotics, and chronotherapy still require rigorous time-standardized human studies.

Chronobiology International
University of Monastir (TN), Hôpital Sahloul (TN), Hospital Fatuma Bourguiba Monastir (TN)
Zero hunger
Openalex Percentile: Top 9%
Gut microbiota and health
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.