Copper-Catalyzed Functionalization of C(sp <sup>2</sup> )–H Bonds with Vinyl Cations: Synthesis of Polycyclic Pyrroles
Catalytic C(sp2)–H functionalization of vinyl cations is an efficient protocol for the construction of new aromatic systems. However, most current methods suffer from noble metal catalysis and low atom economy. Herein, we report a copper-catalyzed C(sp2)–H functionalization of arenes with vinyl cations by a diyne cyclization strategy, leading to the concise synthesis of polycyclic pyrroles. This C(sp2)–H functionalization tolerates both electron-rich and -deficient arenes. Moreover, the related catalytic atroposelective C(sp2)–H functionalization can be realized by chiral copper catalysis.
Authors
- Yue Wang (ORCID: https://orcid.org/0000-0003-0098-5359)
- Maxim A. Novikov
- Bo Zhou (ORCID: https://orcid.org/0000-0002-5551-678X)
- Long-Wu Ye
- Hua-Hong Chen
- Roman A. Novikov (ORCID: https://orcid.org/0000-0002-3740-7424)
- Gongde Wu
Institutions
- Xiamen University (CN)
- Chinese Academy of Sciences (CN)
- Nankai University (CN)
- Nanjing Institute of Technology (CN)
- N.D. Zelinsky Institute of Organic Chemistry (RU)
- Institute of Environmental Engineering (PL)
- State Key Laboratory of Chemical Engineering (CN)
- State Key Laboratory of Organometallic Chemistry
Publication Details
- Journal
- Organic Letters
- Published
- 2026-05-31
- DOI
- https://doi.org/10.1021/acs.orglett.6c01517
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Xiamen City
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Russian Science Foundation