Recent Advances in Methanol‐Involved Interrupted Borrowing Hydrogen Reactions Catalyzed by Transition Metals

ABSTRACT The interrupted borrowing hydrogen (IBH) strategy enables the selective interruption of the complete “dehydrogenation‐transformation‐hydrogenation” process of traditional hydrogen borrowing (BH) reactions via catalytic cycle modulation, thereby facilitating the efficient synthesis of high‐value‐added chemicals inaccessible by conventional methods. This process exhibits excellent atomic economy and step economy, affording only water and hydrogen as by‐products, thereby demonstrating remarkable green and sustainable features. As an abundant, green, and sustainable C1 source, methanol‐mediated IBH reactions have emerged as a prominent research hotspot in organic synthesis and catalysis in recent years. This review comprehensively summarizes recent advances in IBH reactions for the preparation of various organic synthetic building blocks via C─C, C─O, C─N, C─P bond formation reactions using methanol as a methylene bridging reagent under transition metal catalysis.