Harnessing Metabolite Molecular Coassembly for Tunable Supramolecular Architectures and Their Applications

Molecular self‐assembly is widely studied for the production of functional materials with unique physical, chemical, and biological properties. The use of the coassembly approach provides an additional level of complexity for molecular engineering. Specifically, metabolite coassembly represents a versatile and sustainable approach for constructing tunable supramolecular architectures that merge the elegance of biological self‐organization with the functionality of advanced materials. This review summarizes recent developments in understanding the fundamental principles, mechanisms, and applications of metabolite‐based coassemblies. Cooperative noncovalent interactions, such as hydrogen bonding, π–π stacking, hydrophobic, and electrostatic interactions, govern the hierarchical organization of simple bio‐derived molecules into nanostructures, including fibers, sheets, gels, and vesicles. By precisely tuning molecular ratios, solvent conditions, and environmental stimuli, these assemblies exhibit remarkable control over morphology, stability, and functionality. The resulting supramolecular systems display tunable optical, mechanical, and electronic properties, enabling diverse applications in biomedicine, catalysis, sensing, drug delivery, and environmental remediation. Importantly, the inherent biocompatibility, abundance, and chemical simplicity of metabolites underscore their promise as sustainable building blocks for next‐generation soft materials. This review also discusses emerging challenges and future opportunities in rationally designing metabolite‐based coassemblies to achieve adaptive, stimuli‐responsive, and multifunctional materials, providing a roadmap toward sustainable and intelligent supramolecular systems inspired by nature.