Chalcone-Terpene Hybrids from <i>Fissistigma litseifolium</i> (King) Merr as Potential Carbapenemase Inhibitors
species. Phytochemical investigation resulted in the isolation of nine compounds, including three unreported natural products. Of these, fissisteifolin, a quinone, features a unique tetracyclic structure deriving from a chalcone and an uncommon monoterpene. Finally, fissistidin, an original chalcone-sesquiterpene dimer, exhibited 83% reduction in KPC-2 enzyme activity, establishing its potential as a candidate for developing novel carbapenemase inhibitors.
Authors
- Saoussen Oueslati (ORCID: https://orcid.org/0000-0001-5766-3831)
- Cécile Apel (ORCID: https://orcid.org/0000-0003-3785-9620)
- Gaëtan Herbette (ORCID: https://orcid.org/0000-0002-3374-2508)
- Azeana Zahari (ORCID: https://orcid.org/0000-0002-5279-0169)
- Sandy Desrat (ORCID: https://orcid.org/0000-0002-6544-9242)
- Fanny Roussi (ORCID: https://orcid.org/0000-0002-5941-9901)
- Isabel Ramón Martínez
- Emily Cioni
- Thierry Naas (ORCID: https://orcid.org/0000-0001-9937-9572)
- Jean-François Gallard
Institutions
- University of Pisa (IT)
- Centre National de la Recherche Scientifique (FR)
- Institut de Chimie des Substances Naturelles (FR)
- Inserm (FR)
- Université Paris Sciences et Lettres (FR)
- Université Paris-Saclay (FR)
- Ministère de la Santé et de l'Hygiène Publique (ML)
- University of Malaya (MY)
- Assistance Publique – Hôpitaux de Paris (FR)
- Infectious Disease Models and Innovative Therapies (FR)
- CNR de la Résistance aux Antibiotiques (FR)
- Bicêtre Hospital (FR)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2026-05-30
- DOI
- https://doi.org/10.1021/acs.jnatprod.6c00338
- Primary Topic
- Traditional and Medicinal Uses of Annonaceae
- Type
- article
- Field-Weighted Citation Impact
- 0.00