Tubulo-Squamous Vaginal Polyp: A Clinicopathologic Series with Literature Review

Tubulo-squamous polyp (TSP) of vagina is a rare, benign, upper vaginal lesion of postmenopausal women. The origin of TSP is unclear, and the lesion is hypothesized to be arising from misplaced prostate-like vaginal skene glands. We describe the clinical, histological and immunohistochemical features of 6 TSPs we encountered in our routine practice. Histologically, TSPs are characterized by mass-forming, submucosal, cystic metaplastic transitional-type epithelium and prostate-like glands. The histological and immunohistochemical findings in TSP are identical to Mullerian (cervical and vaginal) epithelial metaplastic changes described in a setting of exogenous testosterone exposure.