Semiautomated Online Continuous Flow Injection Analysis – Turbidimetric Determination of Zinc in Pharmaceutical Drugs

This study has assessed the novel technology developed for our in-house NAG-5SX1-1D-SSP analyzer by utilizing the established reaction of the zinc (II) ion with ammonium thiocyanate and mercury (II) chloride to produce a white precipitate. This analyzer was used to access turbidity by calculating the reflection of incident light. The method maintains linear behavior over a concentration range from 0.05 to 18 mmol. L–1, with a detection limit of 0. 489μg.sample–1 and excellent precision (RSD% >1). These results confirmed the reliability and robustness of the developed instrument for Zn (II) determination in various pharmaceutical formulations. Successful detection of Zn (II) ion was achieved in three drug formulations by using the standard addition approach. A comparative analysis was conducted between the newly devised approach and the conventional method (UV-Vis spectrophotometer) at a wavelength of 227 nm through the implementation of an individual and paired t-test. The data obtained underwent rigorous mathematical treatment, revealing no significant variance between the two methodologies in the analysis of three distinct drugs at a 95% confidence level.