Grizaceo/protein-lab: fibromyalgia GWAS-transcriptomics reanalysis.

First stable release of the fibromyalgia GWAS-transcriptomics reanalysis. Preprint: GWAS-Prioritized Neural Genes Are Differentially Expressed in Fibromyalgia PBMCs: A Targeted Reanalysis of Public Transcriptomic Cohorts (Draft v2.0, May 2026) Key scripts: sensitivity_analysis_gse221921.py: Five-model sensitivity analysis (primary). cross_context_gwas_neural_genes.py: PBMC vs. whole blood cross-context comparison. phase2_rct_review.py: Dopamine agonist RCT evidence table. Key results: MDGA2 and DRD2 robustly upregulated in FM PBMCs (5/5 models, sex-adjusted). Cell-fraction-dependent contrast: neural GWAS signal in PBMCs, mast cell panel in whole blood. Pramipexole RCT (Holman & Myers 2005) remains unreplicated after 21 years. Datasets: GSE221921 (PBMC, n=189), GSE67311 (whole blood, n=140) GWAS source: Kerrebijn et al. 2025 (PMID 41001472)