A case of penile intraepithelial neoplasia during treatment with Tofacitinib
A 41-year-old man with PASH syndrome developed high-grade penile intraepithelial neoplasia five months after initiating tofacitinib for refractory disease. Histopathology confirmed PeIN with diffuse p16 and Ki-67 positivity, and the lesions improved after discontinuation of tofacitinib and treatment with cryotherapy and topical imiquimod. This case highlights a potential association between JAK inhibition and HPV-related neoplasia, underscoring the importance of vigilance for mucocutaneous HPV lesions during treatment.
Authors
- Magí Brufau‐Cochs (ORCID: https://orcid.org/0009-0004-2510-4161)
- Irene Fuertes (ORCID: https://orcid.org/0000-0002-9314-1843)
- Natalia Castrejón‐de‐Anta
- Pablo Balado‐Simó
Institutions
- Hospital Clínic de Barcelona (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Clinical and Experimental Dermatology
- Published
- 2026-05-29
- DOI
- https://doi.org/10.1093/ced/llag230
- Primary Topic
- Hidradenitis Suppurativa and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00