Argentatins exert anti-adipogenic and anti-inflammatory effects on 3T3-L1 cells under inflammatory conditions
• Argentatins A and B reduce intracellular lipid accumulation without exhibiting cytotoxicity in 3T3-L1 adipocytes. • Argentatin A increases SIRT1 levels and exerts anti-inflammatory effects. • Argentatin B reduces levels of the pro-inflammatory adipokine resistin. • Argentatin B downregulates PPARγ and C/EBPα expression. • Both argentatins exhibit distinct anti-adipogenic and anti-inflammatory activities.
Authors
- Miguel Ángel de la Cruz-Morcillo (ORCID: https://orcid.org/0000-0002-6674-1333)
- Beatriz G. Gálvez (ORCID: https://orcid.org/0000-0002-8082-9323)
- Carmen Cifuentes
- Cristina Garnés-García
- Manuel Carmona (ORCID: https://orcid.org/0000-0002-8697-8709)
- Silvia García-Dávila (ORCID: https://orcid.org/0009-0009-9109-4279)
- Sílvia Llorens (ORCID: https://orcid.org/0000-0002-2104-5414)
Institutions
- Universidad Complutense de Madrid (ES)
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Servicio de Salud de Castilla La Mancha (ES)
- University of Castilla-La Mancha (ES)
Publication Details
- Journal
- Industrial Crops and Products
- Published
- 2026-05-30
- DOI
- https://doi.org/10.1016/j.indcrop.2026.123521
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Universidad de Castilla-La Mancha
- Junta de Comunidades de Castilla-La Mancha