Clozapine shows benefit in first‐episode psychosis after one failed trial

Individuals with first‐episode psychosis who were switched to clozapine after a failed antipsychotic trial saw greater improvement than those receiving olanzapine or amisulpride, a sequential trial has found. The results offer some evidence to counteract the common recommendation to initiate clozapine only after at least two failed antipsychotic trials. Study results were published online March 11, 2026 in JAMA Psychiatry .

Publication Details

Journal
The Brown University Psychopharmacology Update
Published
2026-05-29
DOI
https://doi.org/10.1002/pu.31462
Primary Topic
Schizophrenia research and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Clozapine shows benefit in first‐episode psychosis after one failed trial

The Brown University Psychopharmacology Update
Schizophrenia research and treatment
article

Clozapine shows benefit in first‐episode psychosis after one failed trial

article en

Abstract

Individuals with first‐episode psychosis who were switched to clozapine after a failed antipsychotic trial saw greater improvement than those receiving olanzapine or amisulpride, a sequential trial has found. The results offer some evidence to counteract the common recommendation to initiate clozapine only after at least two failed antipsychotic trials. Study results were published online March 11, 2026 in JAMA Psychiatry .

The Brown University Psychopharmacology UpdateVol. 37(7)
Openalex Percentile: Top 5%
Schizophrenia research and treatment
DOISourceOpenAlex
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Clozapine shows benefit in first‐episode psychosis after one failed trial · The Brown University Psychopharmacology Update (2026) | TGRS Research Map | TGRS