COMPREHENSIVE REVIEW PAPER MIMOSA PUDICA IN THE TREATMENT OF MIGRAINE

Migraine is a chronic neurological disorder characterized by recurrent episodes of severe headache associated with nausea, vomiting, photophobia, and phonophobia. Despite the availability of several synthetic anti-migraine drugs, their long-term use may lead to adverse effects such as gastric irritation, cardiovascular complications, dependency, and medication-overuse headaches. Therefore, there is increasing interest in herbal medicines with safer therapeutic profiles.Mimosa pudica, commonly known as the “touch-me-not” or “sensitive plant,” is a medicinal herb widely used in Ayurveda, Siddha, and folk medicine systems. The plant possesses various pharmacological activities including anti-inflammatory, analgesic, antioxidant, anxiolytic, neuroprotective, and anticonvulsant properties, which may contribute to its potential effectiveness in migraine management. The bioactive constituents such as alkaloids, flavonoids, tannins, glycosides, terpenoids, and mimosine are believed to modulate inflammatory mediators and oxidative stress involved in migraine pathophysiology.This review summarizes the botanical description, phytochemical constituents, pharmacological activities, possible mechanism of action against migraine, marketed formulations used for migraine therapy, traditional medicinal uses, and future research perspectives of Mimosa pudica. The review also highlights the need for clinical investigations to validate its efficacy and safety as an alternative herbal remedy for migraine treatment.