Decision‐support tool shows promise for treatment retention in depression

A decision‐support tool for antidepressant treatment that considers demographic, clinical, and patient preference factors was more effective than usual care in retaining patients in treatment at 8 weeks, a randomized trial has found. Individuals whose antidepressant choice was based on application of the PETRUSHKA (Personalizing Antidepressant Treatment for Unipolar Depression Combining Individual Choices, Risks and Big Data) tool also saw greater improvement in symptoms of depression and anxiety at 24 weeks.

Publication Details

Journal
The Brown University Psychopharmacology Update
Published
2026-05-29
DOI
https://doi.org/10.1002/pu.31465
Primary Topic
Treatment of Major Depression
Type
article
Field-Weighted Citation Impact
0.00
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article

Decision‐support tool shows promise for treatment retention in depression

The Brown University Psychopharmacology Update
Treatment of Major Depression
article

Decision‐support tool shows promise for treatment retention in depression

article en

Abstract

A decision‐support tool for antidepressant treatment that considers demographic, clinical, and patient preference factors was more effective than usual care in retaining patients in treatment at 8 weeks, a randomized trial has found. Individuals whose antidepressant choice was based on application of the PETRUSHKA (Personalizing Antidepressant Treatment for Unipolar Depression Combining Individual Choices, Risks and Big Data) tool also saw greater improvement in symptoms of depression and anxiety at 24 weeks.

The Brown University Psychopharmacology UpdateVol. 37(7)
Openalex Percentile: Top 7%
Treatment of Major Depression
DOISourceOpenAlex
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Decision‐support tool shows promise for treatment retention in depression · The Brown University Psychopharmacology Update (2026) | TGRS Research Map | TGRS