The Potential Role of Topical Skincare Approaches After Glucagon-like Peptide-1 Receptor Agonist Use and Rapid Weight Loss

BACKGROUND: Diminished facial and body skin qualities have emerged as unintended consequences of rapid weight loss associated with glucagon-like peptide-1 receptor agonists (GLP-1RAs). Patients experiencing facial and body skin sagging (laxity) are increasingly seeking corrective treatments to address aesthetic concerns. OBJECTIVE: To present available information on the effectiveness of topical skincare in addressing post-weight loss concerns such as skin quality and sagging/laxity. MATERIALS AND METHODS: A literature review was conducted to assess mechanisms underlying skin effects of GLP-1RA and rapid weight loss, and the role of topical skincare in addressing skin quality and sagging/laxity. RESULTS: GLP-1RA effects on subcutaneous adipose tissues and the dermal extracellular matrix include dehydration and nutrient deficiencies, and may lead to reduced skin quality and fibroblast function, decreased production of collagen, and increased degradation of collagen, elastic fibers, and glycosaminoglycans, causing loss of elasticity and skin sagging/laxity. Recent advances in skincare research have identified growth factors, peptides, and botanical extracts with potential rejuvenating effects on skin. Clinical studies have validated the effectiveness of topical formulations in improving facial and body skin sagging/laxity. CONCLUSION: Topical skincare formulations with demonstrated effectiveness in improving skin quality and sagging/laxity may be important adjuncts to post-weight loss multimodal aesthetic treatments.