Diagnostic Features of Discogenic Low Back Pain: A Narrative Review and Suggested Areas for Future Research and Clinical Practice

ABSTRACT Background Chronic low back pain is a leading cause of global disability, with discogenic low back pain (DLBP), mechanically stimulated pain arising from the intervertebral disc, representing an important but often under‐recognized subtype. DLBP arises from chronic structural and metabolic changes within the intervertebral disc, leading to inflammation, nerve ingrowth, and nociceptive sensitization. Diagnosis remains difficult due to overlapping symptoms, non‐specific imaging, and the lack of a universally accepted reference standard. Accurate identification is critical for guiding effective management. This review aims to summarize and evaluate current and proposed diagnostic features of DLBP. Methods A narrative literature review was conducted using PubMed, Scopus, and Web of Science, with supplementary hand searching and citation tracking. Studies evaluating clinical or investigative diagnostic features of DLBP were included, without restriction on study design. Studies involving neural compression, radiculopathy, or non‐DLBP were excluded. Evidence was thematically synthesized, with preference given to higher‐quality or larger studies where findings overlapped. Results No clinical features have been consistently validated as predictive of DLBP. Flexion‐based postures, movements, and prolonged sitting demonstrate modest diagnostic value, while traditional features such as axial loading or Valsalva maneuvers lack supporting evidence. Imaging findings, including Modic changes, high‐intensity zones, and Pfirrmann grading, show limited specificity. Provocative discography is constrained by invasiveness, complications, and questionable reliability. Emerging metabolic imaging techniques demonstrate early potential as future reference standards. Evidence of clinical prediction models for DLBP remains limited. Conclusions DLBP diagnosis remains constrained by non‐specific features and imperfect reference standards. Emerging metabolic imaging techniques warrant further validation, alongside development of robust diagnostic models to improve clinical decision making.

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Publication Details

Journal
JOR Spine
Published
2026-05-28
DOI
https://doi.org/10.1002/jsp2.70195
Primary Topic
Spine and Intervertebral Disc Pathology
Type
article
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0.00
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article

Diagnostic Features of Discogenic Low Back Pain: A Narrative Review and Suggested Areas for Future Research and Clinical Practice

William Roger Peters, Mario Giuseppe Zotti, Ashish D. Diwan
JOR Spine
Spine and Intervertebral Disc Pathology
article

Diagnostic Features of Discogenic Low Back Pain: A Narrative Review and Suggested Areas for Future Research and Clinical Practice

William Roger Peters, Mario Giuseppe Zotti, Ashish D. Diwan
article en

Abstract

ABSTRACT Background Chronic low back pain is a leading cause of global disability, with discogenic low back pain (DLBP), mechanically stimulated pain arising from the intervertebral disc, representing an important but often under‐recognized subtype. DLBP arises from chronic structural and metabolic changes within the intervertebral disc, leading to inflammation, nerve ingrowth, and nociceptive sensitization. Diagnosis remains difficult due to overlapping symptoms, non‐specific imaging, and the lack of a universally accepted reference standard. Accurate identification is critical for guiding effective management. This review aims to summarize and evaluate current and proposed diagnostic features of DLBP. Methods A narrative literature review was conducted using PubMed, Scopus, and Web of Science, with supplementary hand searching and citation tracking. Studies evaluating clinical or investigative diagnostic features of DLBP were included, without restriction on study design. Studies involving neural compression, radiculopathy, or non‐DLBP were excluded. Evidence was thematically synthesized, with preference given to higher‐quality or larger studies where findings overlapped. Results No clinical features have been consistently validated as predictive of DLBP. Flexion‐based postures, movements, and prolonged sitting demonstrate modest diagnostic value, while traditional features such as axial loading or Valsalva maneuvers lack supporting evidence. Imaging findings, including Modic changes, high‐intensity zones, and Pfirrmann grading, show limited specificity. Provocative discography is constrained by invasiveness, complications, and questionable reliability. Emerging metabolic imaging techniques demonstrate early potential as future reference standards. Evidence of clinical prediction models for DLBP remains limited. Conclusions DLBP diagnosis remains constrained by non‐specific features and imperfect reference standards. Emerging metabolic imaging techniques warrant further validation, alongside development of robust diagnostic models to improve clinical decision making.

JOR SpineVol. 9(2)
Bond University (AU), Royal Adelaide Hospital (AU), Sutherland Hospital (AU), Gold Coast Hospital (AU), St George Hospital (AU), Gold Coast Health (AU), Sydney Orthopaedic Research Institute (AU)
Peace, Justice and strong institutions
Openalex Percentile: Top 5%
Spine and Intervertebral Disc Pathology
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