Comparative activity of ceftibuten combinations with avibactam, ledaborbactam, and xeruborbactam against recombinant β-lactamase-producing <i>Escherichia coli</i> and contemporary WGS-characterized strains of carbapenemase-producing Enterobacterales
ABSTRACT We evaluated the activity of ceftibuten combinations with avibactam, ledaborbactam, and xeruborbactam against isogenic Escherichia coli and clinical Enterobacterales isolates producing broad-spectrum β-lactamases. Avibactam and ledaborbactam enhanced ceftibuten activity against transformants producing serine-β-lactamases. Ceftibuten/xeruborbactam was also active against VIM and some IMP producers. All combinations were active against OXA-48- and KPC-producing clinical isolates. Ceftibuten/xeruborbactam also retained activity against VIM-producing clinical strains. Susceptibility rates for MBL producers varied, depending on the CLSI or EUCAST breakpoints applied.
Authors
- Salud Rodríguez-Pallares (ORCID: https://orcid.org/0000-0002-8270-0259)
- Alejandro Beceiro (ORCID: https://orcid.org/0000-0002-6340-7815)
- Belén Aracil García
- Tania Blanco-Martín (ORCID: https://orcid.org/0009-0003-1636-6429)
- Jorge Arca-Suárez (ORCID: https://orcid.org/0000-0002-4248-503X)
- Lucía Sánchez-Peña (ORCID: https://orcid.org/0009-0007-5696-5812)
- Gloria Pérez-Rodríguez (ORCID: https://orcid.org/0009-0002-8039-6641)
- Pablo Aja-Macaya (ORCID: https://orcid.org/0000-0001-6296-5949)
- Lucía González-Pinto (ORCID: https://orcid.org/0000-0002-8387-3784)
- Germán Bou (ORCID: https://orcid.org/0000-0001-8837-0062)
- Inmaculada López-Hernández (ORCID: https://orcid.org/0000-0002-0204-1303)
Institutions
- Universidade da Coruña (ES)
- Instituto de Salud Carlos III (ES)
- Hospital Universitario Virgen Macarena (ES)
- Instituto de Biomedicina de Sevilla (ES)
- Instituto de Investigación Biomédica de A Coruña (ES)
- Universidad de Sevilla (ES)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2026-05-29
- DOI
- https://doi.org/10.1128/aac.00195-26
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Axencia Galega de Innovación
- Instituto de Salud Carlos III