Potential for risk reduction of chronic health conditions through lifestyle in childhood cancer survivors
Childhood cancer survivors are at high risk for treatment-related chronic health conditions. How much of this risk can be attributed to lifestyle is not known. In this study, we assess associations between lifestyle and a range of chronic health conditions and estimate lifestyle-specific population attributable fractions for chronic health conditions in survivors and compare them to those of radiotherapy and chemotherapy. Here we show that unhealthy lifestyle is associated with higher risk for subsequent hypertension, dyslipidemia, diabetes, heart attack, heart failure, valvular disease, joint replacement, anxiety, depression, and impaired physical and mental quality of life. Disease proportions attributed to unhealthy lifestyle exceed those of chemotherapy and radiotherapy for hypertension, diabetes, joint replacement, anxiety, depression, and impaired physical and mental quality of life. Unlike previous cancer treatment exposures, lifestyle can be modified. We need to further develop and implement effective lifestyle interventions in childhood cancer survivors, promoting healthy weight and physical activity.
Authors
- Y YASUI
- Shizue Izumi (ORCID: https://orcid.org/0000-0001-5943-4936)
- Deo Kumar Srivastava (ORCID: https://orcid.org/0000-0001-6693-8120)
- Aron Onerup (ORCID: https://orcid.org/0000-0002-1946-3529)
- Lenat Joffe (ORCID: https://orcid.org/0000-0001-6094-9697)
- Lucie M. Turcotte (ORCID: https://orcid.org/0000-0003-4106-6172)
- Tara M. Brinkman
- Claire Snyder
- Matthew J. Ehrhardt (ORCID: https://orcid.org/0000-0003-2781-9983)
- Kevin C. Oeffinger (ORCID: https://orcid.org/0000-0003-0806-7894)
- Rebecca M. Howell
- Gregory T. Armstrong
- Paul C. Nathan
- Kirsten K. Ness (ORCID: https://orcid.org/0000-0002-2084-1507)
- Qi Liu (ORCID: https://orcid.org/0000-0002-7208-515X)
- Stephanie B. Dixon (ORCID: https://orcid.org/0000-0003-3901-3274)
Institutions
- University of Minnesota (US)
- Northwell Health (US)
- St. Jude Children's Research Hospital (US)
- The University of Texas MD Anderson Cancer Center (US)
- Johns Hopkins University (US)
- University of Alberta (CA)
- Shiga University (JP)
- University of Toronto (CA)
- Hospital for Sick Children (CA)
- Cohen Children's Medical Center (US)
- Duke Medical Center (US)
- SickKids Foundation (CA)
- University of Gothenburg (SE)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-05-29
- DOI
- https://doi.org/10.1038/s41467-026-73517-y
- Primary Topic
- Childhood Cancer Survivors' Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- St. Jude Children's Research Hospital
- American Lebanese Syrian Associated Charities
- Vetenskapsrådet
- Göteborgs Läkaresällskap
- Göteborgs Universitet
- Barncancerfonden
- National Cancer Institute