Enantioselective Construction of Cyclopentene Spiroindene Scaffolds via Phosphine-Catalyzed Annulation of Benzofulvene with MBH Carbonates
A novel chiral amide-phosphine bifunctional catalyst was developed and successfully catalyzed the asymmetric intermolecular vinylogous [3+2] annulations of MBH carbonates with benzofulvenes, affording cyclopentene spiroindenes with excellent regioselectivity and stereoselectivity (up to >20:1 dr and >99% ee), which are widely present in natural products and chiral catalysts.
Authors
- Shenhuan Li
- Yuanjing Xiao (ORCID: https://orcid.org/0000-0002-0185-1961)
- Xun-Shen Liu (ORCID: https://orcid.org/0000-0002-3821-1271)
- Zhi‐Yao Si
- Zhenli Liu (ORCID: https://orcid.org/0009-0001-0628-3131)
- Lu Liu
- Yiyuan Cheng
- Junliang Zhang (ORCID: https://orcid.org/0000-0002-4636-2846)
Institutions
- Fudan University (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-05-29
- DOI
- https://doi.org/10.1021/acs.orglett.6c01783
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China