Enhancing the specificity of microglia genetic targeting using a CSF1R inhibitor
mice and eliminated confounding contributions from peripheral macrophages. In sum, the use of a CSF1R inhibitor provides a solution to enhance the precision of microglial genetic manipulation using a common Cre line.
Authors
- Tajie H. Harris (ORCID: https://orcid.org/0000-0002-1355-2109)
- Anne E Marchildon (ORCID: https://orcid.org/0000-0002-1683-4160)
- Sydney A. Labuzan (ORCID: https://orcid.org/0000-0002-5967-4523)
- Abigail Kelly
- Seblework Alemu
- Anne E. Schuster
- Isaac W. Babcock
- Lydia A. Sibley
Institutions
- University of Virginia (US)
Publication Details
- Journal
- Cell Reports
- Published
- 2026-05-30
- DOI
- https://doi.org/10.1016/j.celrep.2026.117411
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Virginia
- School of Medicine, University of Virginia
- National Institute of General Medical Sciences
- National Institute of Allergy and Infectious Diseases
- National Institute of Neurological Disorders and Stroke