Therapeutic Efficacy of ASA-ALN-CDs in Periodontitis: From Antibiofilm/Anti-Inflammation to Alveolar Bone Regeneration
, high bone-targeting ability, and good cytocompatibility. The material suppressed LPS-induced IL-1β and IL-6 expression and promoted osteogenic differentiation of MC3T3-E1 cells under inflammatory conditions. In a rat periodontitis model, local administration of ASA-ALN-CDs reduced alveolar bone loss and inflammation. Mechanistically, ASA-ALN-CDs inhibited the HIF-1α signaling pathway and downregulated LDHA and VEGF. Collectively, ASA-ALN-CDs represent a promising bone-targeting nanoplatform integrating antibacterial, anti-inflammatory, and pro-osteogenic functions for periodontitis therapy.
Authors
- H. Li
- J. Wang
- M Wang
- Yuanbo Zhan (ORCID: https://orcid.org/0000-0003-0416-8911)
- Jiaqi Kong
- Wenxia Xu (ORCID: https://orcid.org/0000-0002-9018-4784)
- Sen Mu (ORCID: https://orcid.org/0009-0003-2466-4477)
- Ying Yan
- Nan Miao
- Xinru Guo
- Chubo Yang
Institutions
- Harbin Medical University (CN)
- Harbin Institute of Technology (CN)
- British Society of Periodontology (GB)
- Tissue Regeneration Systems (United States) (US)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- ACS Biomaterials Science & Engineering
- Published
- 2026-05-29
- DOI
- https://doi.org/10.1021/acsbiomaterials.6c00315
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Heilongjiang Province